1169 results
The objectives of the study are twofold:1) Determination of the absolute values and variability of PSMA uptake in tumour tissue and in normal tissues, including muscles, liver, spleen, bone marrow2) Determination of the absolute values and…
In this study, we aim to investigate the difference in the anabolic postprandial bile acid response between an enteral and parenteral mixed meal test (MMT) in healthy lean men. This study is important because it may give a better understanding of…
Primary Objective: To study the differences between EB post oxygen-dive, post air-dive (control), dry-dive (recompression chamber) and pre-dive (baseline).1. Will an exposure to a PO2 of 190 kPa (100% oxygen at 9 msw) during 60 minutes in an…
The primary objective of this study is to describe the quality and content of electrical brain responses of pain free subjects to electrocutaneous stimuli during multiple threshold tracking, by determining the signal-to-noise ratio of averaged…
Determination of microbiological, macro and microscopic / histological characteristics after RYGB, mainly targeted at identifying inflammatory characteristics, bacterial (over) growth and / or atrophy / metaplasia in the excluded stomach and the…
To determine whether the adapted Sternberg short-term working memory task (STMST) is an effective method to induce emotional stress-induced malodour.
The purpose of the study is to investigate how quickly and to what extent 2 different production batches of FT218 (batch A and batch B) are absorbed and eliminated from the body (this is called pharmacokinetics). In this study it is investigated…
We propose an observational clinical trial in critically ill patients to investigate the effect and duration of platelet transfusion on coagulation, including platelet function and markers of endothelial activation in critically ill patients.
The primary objective is to evaluate plasma levels of A*1*42/A*1*40 ratio, A*1*40, A*1*42, neurofilament light (NFL), t*tau and anti*tau antibodies as disease*specific markers for AD. The secondary objective is to measure biological age parameters (…
The purpose of this study is to investigate how quickly and to what extent PF-06650833 is absorbed, distributed, metabolized (broken down) and eliminated from the body (this is called pharmacokinetics). PF-06650833 is not registered as a drug, but…
- To evaluate the pharmacokinetic (PK) profile of the combination of GLPG3067, GLPG2222, and GLPG2737 following repeated morning versus evening doses given to healthy female subjects - To evaluate the safety and tolerability of the combination of…
PrimarySafety and tolerability of MVT-602 following single dose subcutaneous administration in healthy premenopausal womenSecondaryPharmacokinetics (PK) and pharmacodynamics (PD) of MVT-602 following single dose subcutaneous administration
Our primary objective is to identify de novo/rare mutations causative of MS using WES in members of multi-incident families. Our secondary objective is to describe phenotypes per family using questionnaires and semi-structured interviews with family…
The purpose of this study is to investigate how safe the new compound FLX475 is when it is administered to healthy subjects. FLX475 has not been administered to humans before. It has been previously tested in the laboratory and on animals. FLX475…
To generate a set of normal values in people over 60 that can be expected to have an normal immune system, in order to be able to interpret the immune system of eldery patients with repeated airway infections.
The aim of the project is to study the effect of COM test compounds on typical skin features of psoriasis. This information can establish the most effective compound, right formulation and dose for further clinical research.
Primary objective:* To compare the bioavailability of different dry powder formulations of tiotropium bromide in healthy volunteersSecondary objectives:* To compare the safety and tolerability of different dry powder formulations of tiotropium…
To investigate the potential influence of time of dosing (morning or evening)on the bronchodilator effect of once daily orally inhaled QVM149 compared toplacebo.
FT218 is a new formulation (composition) of the registered drug sodium oxybate. Sodium oxybate (also known as the sodium salt of gamma-hydroxybutyric acid [GHB]) is registered under the name Xyrem® for the treatment of narcolepsy. The purpose of…
To identify the most effective and safe long-term S. aureus carriage decolonization strategy in HPN patients. Ultimately this willlead to less antimicrobial resistance, less catheter removals and lower mortality rates. Also, other chronic…