16425 results
Objectives:Primary Objective:* To compare the overall survival (OS) distributions of RP101 and gemcitabine to placebo and gemcitabine in subjects with unresectable, locally advanced or metastatic pancreatic adenocarcinomaSecondary Objectives:* To…
To demonstrate superiority of XP chemotherapy regimen plus cetuximab versus XP alone asfirst-line treatment for advanced gastric cancer in terms of PFS. To assess cetuximab + XP versus XP alone with respect to: OS; overall response; QoL; safety.
The goal of this study is to perform a kinematic evaluation of the Duracon knee prosthesis (Stryker, USA), by means of fluoroscopy and EMG. The findings of this study will contribute to improve total knee designs and improve rehabilitation…
It is the goal of this study to evaluate the additional value of the Philips Rehabilitation Exerciser for task-oriented training of arm-hand function in chronic stroke patients. Research questions:1) Does an 8 week technology-assisted task-oriented…
The aim of this randomized controlled trial (RCT) will be: To assess the effectiveness of the e-therapy program for problem drinking. The research questions of this study are: 1. Is an e-therapy program with therapist involvement, based on cognitive…
The object of this study is to determine the effect of a cognitive behavioral self help intervention for insomnia. It will be tested if internet delivered self-help differs from self-help via a booklet.
The objective of this study is to determine the prevalence of xerostomia after radiotherapy of oropharyngeal tumors when sparing the parotid glands and one submandibular gland.
To establish platelet function and primary hemostasis during lung transplantation
The primary aim of the proposed multi-site study will be to determine internal and external validity of the proposed new diagnostic criteria.
The aim of the experiment is to test whether people who catastrophize about pain stop sooner with a task in a negetaive mood than in a positive mood
Primary objective:1. Compare the clinical and functional outcome in the function of the knee between resurfacing the patella and not resurfacing the patella in patients with a Vanguard* Complete Knee System (Biomet Orthopedics, Inc.) total knee…
The goal of the proposed study is to investigate a preexisting psycho-biochemical risk profile for major adverse cardiovascular events (MACE) and patient perceived symptoms in a group with angiographically confirmed, but non-acute, coronary artery…
This study investigates if there are differences in function and wear between total hip arthroplasty with standard or large diameter femoral heads.
Primary Objective: To assess the effect of treatment with three doses of botulinum toxin type-A (Dysport®) versus placebo on the number of episodes of urgency and frequency of micturition experienced in continent female subjects with idiopathic…
The objective of this trial is to demonstrate that bosentan delays disease worsening or death in patients with IPF.
Is het possible to determine the presence of disseminated tumor cells in blood in patients with colonic cancer who are operated upon laparoscopiccaly?
The objective of this study is to compare in healthy subjects the effects of a HF diet (40 En% fat) with those of a LF diet (20 En% fat) on early biomarkers and parameters of metabolic stress in blood and on expression of genes in the small…
This study aims to investigate whether the definition of a fixed volume limit of 500 ml can be changed to a bladder volume limit adapted to each individual*s own maximum bladder capacity. It is expected that this change in definition will lead to…
The objective of the trial is to compare the efficacy and safety of treatment with Allovectin 7® versus treatment with DTIC or TMZ in subjects with recurrent metastatic melanoma. The results of the trial will be used to support registration of…
Objective #1: Implement clinical platform. We see the need to implement a clinical platform for two purposes. First, we want to design a biomarker profile of perinatal brain damage in human newborns (see above). Thus, we have established a…