38 results
To determine the effect of transfusion on the expression of PS in critically ill patients with and without inflammation.
The primary objective of the study is to evaluate the efficacy of treatment with AG-348, as assessed by the reduction in transfusion burden.Secondary: The secondary objective of this study is to evaluate the safety of treatment with AG 348.
* The purpose of this study is to to determine the safety profile of long-termCoversin treatment.* To observe the long term safety and efficacy of Coversin over periods in excess of 6 months* To assess the long term patient acceptability of Coversin…
Two main research questions:- improving the knowledge of the pathofysiologic mechanisms of immune tolerance induction (ITI)- determining what type of factor VIII product (based on pathophysiology and an in-vitro model of ITI) is the most effective…
The first objective is to explore whether epo regulation and expression, at the age of two weeks after birth and three to six months post-term, are associated with the course of Hb levels. Furthermore, we will assess if epo regulation and expression…
In this study, the genetic risk factors and time dependent risk factors for alloimmunization will be analyzed. Furthermore, the role of the innate and adaptive immune system on allo-antibody formation in SCD patients will be elucidated.
Main objective: - To investigate pyruvate kinase thermal stability in haemoglobinopathies.Secondary objectives: - To investigate the possibility of stimulation of PK activity and thermal stability by use of allosteric activators- To investigate…
The primary aim of this project is to analyze the association between factor VIII and factor IX plasma levels and the bleeding phenotype.
Primary Objective: The primary objective of this study is to identify whether the Geko system can augment flow compared to IPCS in post-thrombotic limbs before after stenting.(group 1) In group 2 we want to identify whether the Geko with occluded…
Primary Objective:The purpose of Part A is to determine whether sutimlimab administration results in a greater than or equal to (>=)1.5 gram per deciliter (g/dL) increase in hemoglobin (Hgb) level and avoidance of transfusion in participants…
Our aim is to assess the sequential response of different endothelial markers following DDAVP administration. This information will be used to expand the population PK model and may enhance our insight in the mechanisms underlying the DDAVP response…
Primary aim:- What is the increase in hemoglobin concentration between epoetin alpha injection number three and four in patients awaiting orthopedic surgery?Secondary aim:- What is de increase in hemoglobin concentration between epoetin alpha…
To establish whether or not DPD deficient patients suffer from an altered white blood cell homeostasis or function, in particular of B or T lymphocytes.
The purpose of the study is to compare LA-EP2006 and Neulasta®US and Neulasta®EU with respect to how quickly and to what extent the compounds are absorbed and eliminated from the body after injection under the skin of the abdomen (this is called…
Our primary objective is to test our hypothesis that lower Hb thresholds than the current ones, provided adequate cerebral oxygen saturation values are met, will lead to a better neurological outcome in preterm infants at three monts post-term. Our…
The main objective is to collect data on effect size for, and determine the feasibility of, a full scale RCT to assess the effect of dosing per 0.5 mg acenocoumarol on quality of anticoagulation, treatment satisfaction, and medication errors.
To establish if miRNA-19b-1-5p measured in PRP correlates with platelet aggregation.
Primary Objective: To compare the extent of haemolysis associated with the use of the conventional versus the miniaturised heart lung machine in the Amphia hospital, with the aim to set up evidence-based guidelines for the use of a specific type of…
To investigate the effect of monitored strenuous exercise at high altitude on blood coagulation, more specifically on thrombin generation, platelet function and fibrinolysis.
We propose an observational clinical trial in critically ill patients to investigate the effect and duration of platelet transfusion on coagulation, including platelet function and markers of endothelial activation in critically ill patients.