298 results
To measure APC resistance and SHBG levels as indicators of the risk of venous thrombosis during use of the new developed combined oral contraceptive containing dienogest/estradiolvalerate (Qlaira®) compared with a combined oral contraceptive…
Primary:- to assess the multiple-dose pharmacokinetics of apixaban and rivaroxaban - to compare plasma concentration peak to trough ratio (Cmax/Cmin) of rivaroxaban to apixaban Secondary:- to assess the multiple dose pharmacodynamics (anti-Factor Xa…
To evaluate the efficacy of incentive spirometry on the incidence of ACS in adult sickle cell patients admitted with a vaso-occlusive painful crisis.
The aim of this study is to investigate if there is a correlation between the clinical phenotype (defined as age of first bleeding and bleeding score) of patients with severe haemophilia A and the results of the whole clotting assessment (TM-ETP + T…
The primary objective of this study is to confirm the efficacy and safety of Genz 112638 after 39 weeks of treatment in patients with Gaucher disease type 1.The secondary objective of this study is to determine the long term efficacy, safety, and…
Primary Objective•To assess the pharmacodynamic response after single dose administration of NOX H94 in healthy subjects during experimental endotoxemia.Secondary Objective• To determine the pharmacodynamic effects of NOX H94 after single dose…
- Primary objective:To evaluate the flow cytometric characteristics of the bone marrow compartment before and during treatment with Exjade® in low and intermediate-I risk myelodysplastic syndromes.- Secondary objectives:To correlate the flow…
Testing the hemostasis of oral surgery wounds with the HemCon dental dressing in patients on oral anticoagulation therapy
-To assess the feasibility of relatively frequent measurements of whole blood platelet aggregometry using collagen as inducer;-To assess the effects of ASA treatment on collagen-induced platelet aggregation (primary endpoint);-To investigate the…
A study to investigate the safety, pharmacokinetics and pharmacodynamics of a new recombinant human factor VIIa in healthy males, compared to Novoseven.
The objectives of the complete NIMBL study are as follows:Objective 1. Gain insight into the natural history of AGS and RVCL* Create a registry of paediatric and adult AGS and RVCL patients, and develop a network of clinicians caring for these…
In this study, we will assess whether healthy men with high-normal serum CK display attenuated platelet aggregation, compared to those with low-normal serum CK.
The aim of this study is to investigate whether exercise changes FVIII levels in patients with moderate and mild haemophilia.
Primary: to evaluate the pharmacokinetics of a single 100 mg dose of CAL-101 administered as a capsule (unmicronized formulation), a capsule (micronized formulation) or a tablet in normal healthy male subjectsSecondary: to evaluate the safety of a…
The aim of the study is to understand the effects of CPB on coagulation and fibrinolysis to improve treatment of excessive blood loss (>2L/24 hours or >200 mL/hour) after cardiac surgery.The objective of this study is to differentiate…
• to evaluate the safety and tolerability of ascending single oral doses of the test compound ACT-389949 (test medication) in healthy male subjects• to study how the test compound ACT-389949 is absorbed, broken-down and excreted by the body and how…
The primary objective is to assess the clinical efficacy of siltuximab (a chimeric (murine-human) IgG1* mAb that specifically binds human IL-6 with high affinity and prevents its interaction with the IL-6 receptor, glycoprotein (GP) 80),…
Primary objective:Determine the incidence rate of inhibitor formation in PUPs with severe and moderately severe hemophilia A during the first 50 exposure days (EDs) to starting with a once weekly prophylactic regimen together with the minimization…
To get more insight into the T cell homeostasis in lymfocytopenic, ATG treated patients and normocytopenic patients treated with standard maintenance immunosuppressive drug therapy.
The primary objective of this study is to establish a panel of markers that can be used for further research into the understanding of the pathogenesis of PTS.