65 results
To see whether C. burnetii is able to induce epigenetic changes in monocytes, resulting in a more distinct pro-inflammatory response to re-stimulation with viral particles, to see whether these changes are present in circulating monocytes of QFS…
The aim of the study is to assess the feasibility of conducting a definitive trial in terms of recruitment, use and acceptability of H@H, quality of care and the advantages and disadvantages of H@H in comparison to usual hospital care.
The main objective is to investigate the additional value of CRP-POCT (C-reactive protein point-of-care-test) testing in patients suspected of airway infections in long-term care facilities.
To investigate the long term (ten years) protective immune response to fractional yellow fever vaccination (1/5th of the standard dose, injected intradermally), compared to the standard subcutaneous vaccination
To identify the most effective and safe long-term S. aureus carriage decolonization strategy in HPN patients. Ultimately this willlead to less antimicrobial resistance, less catheter removals and lower mortality rates. Also, other chronic…
Primary objectives:1) To evaluate the safety of CHMI-trans protocols in healthy malaria-naïve volunteers challenged with Plasmodium falciparum by sporozoite challenge and blood stage challenge. 2) To assess gametocyte infectiousness for Anopheles…
To investigate whether the current dosing regimen of ciprofloxacin, recommended by the Dutch *Stichting Werkgroep Antibioticabeleid* (SWAB) and applied at the Academic Medical Center for patients with various degrees of renal function admitted at…
The objectives of this study are: 1) To assess the user friendliness of the DBS self-sampling technique.2) To assess the quality of ssDBS.3) To estimate the agreement between viral loads in ssDBS and laboratory spotted DBS (labDBS).
We hypothesise that antibiotic-corticosteroid eardrops are non-inferior to oral antibiotics in resolving ear pain and fever at day 3 (72 hours after randomisation) in children aged 6 months to 12 years visiting their GP with AOMd and either ear pain…
A decrease in the incidence of central line-associated bloodstream infections in the investigational study group, compared to the control group.
To determine the effect of transfusion on the expression of PS in critically ill patients with and without inflammation.
Primary objectivesTo determine the bacterial eradication capacity of ertapenem, fosfomycine and gentamicine compared to the reference treatment (ceftriaxone) in uncomplicated anogenital gonococcal infections (at one included infection site) by…
Primary objectives1. Determine prospectively the accuracy of proposed clinical criteria to assess the risk of SA-IE and complicated SAB2. Determine the diagnostic accuracy of cCT for SA-IE in patients with SAB3. Determine the diagnostic and…
To investigate the safety and tolerability of controlled human urine transfusion in female patients with recurrent UTI*s.
- To assess the effectiveness of rectal culture-guided antimicrobial prophylaxis for transrectal prostate biopsy (random ultrasound-guided, targeted MRI-guided or targeted MRI-ultrasound fusion guided) on infectious complications. - To compare the…
I.To assess the utility of point-of-care measurements of blood CRP and PCT levels to support clinical rules for diagnosing urinary tract infections UTI in nursing home residents.II. To develop and assess strategies that facilitate implementation of…
Primary Objective: To isolate B-cells producing bNAbs against EVs from healthy human individuals and to generate bNAbs from these B-cells for the development of a novel EV immunotherapy. Secondary Objective(s): To further elucidate the humoral…
The aim of this study is to analyze the long-term effect of full-mouth tooth extraction and subsequent implant placement on the oral microflora (colonization of implants), using 16S next-generation sequencing technique. A secondary aim is to analyse…
Achieving more detailed information about the possible auto-immune process that underlies narcolepsy by:(1) Assessing differences in immune composition between peripheral blood samples of healthy controls (n=30) and type 1 narcolepsy patients (n=30…
Primary objective:To establish four healthy donors for future CHHI studies