1298 results
The objective of this project is to investigate uptake, usability and acceptability of two hiv prevention interventions. These relate to the use of biomedical interventions, ie the provision of daily and intermittent PrEP to men who have sex with…
To investigate whether a 200 mg bid fixed dosage regimen of ciprofloxacin achieves concentrations associated with maximal efficacy and minimal spread of resistance in ICU patients undergoing CVVHD.
To determine the effectiveness and, subsequently, the cost-effectiveness of a endoscopic transluminal step-up approach (ETD & ETN) versus a surgical step-up approach (PCD & VARD ,if not possible laparotomy) to improve clinical…
Our study will measure several different symptoms/aspects of cellulitis, such as redness, swelling, warmth, pain, fluctuation, ulceration and drainage. Each of these aspects will be scored on a scale of 0-3, adding up to a maximum total score of 21…
Primary• To determine changes over time, since introduction of PCV vaccination in National Immunization Program, in nasopharyngeal colonization frequencies of total vaccine- and non-vaccine serotypes of S. pneumoniae in healthy 24-month-old and 46-…
Primary Objectives:The primary objectives are to evaluate in infants who are hospitalized with RSV infection:- the pharmacokinetics of JNJ-53718678 after multiple oral doses;- the safety and tolerability of JNJ-53718678 when administered for 7 days.…
Our primary objective is to investigate whether noradrenaline exerts immunomodulatory effects in humans in vivo during experimental human endotoxemia. This will be determined by comparing plasma levels of various pro- and anti-inflammatory cytokines…
1. To examine whether epigenetic inhibitors can reverse exhaustion of HIV-specific CD8+ T cells.2. To determine whether HIV-specific CD8+ T cells have altered expression of post-transcriptional regulators.
Primary ObjectiveTo determine the prevalence of respiratory viral colonization/infection in pre-term born neonates during hospitalisation.Secondary Objectives1. To study the relation of viral respiratory colonization with respiratory support2. To…
Primary ObjectiveTo evaluate and compare the pharmacokinetic (PK) parameters (AUC0-t, AUC0-inf, Cmax, C24hr, Tmax, and apparent t*) of MK-3682 and its circulating metabolites MK-5172, and MK-8742 following administration of three test premarket…
In this study we want to assess the quality of vaccination status in Dutch families after travel and compare how well they are protected against infectious diseases as prescribed by national vaccination protocolsSecondary, we want to study the…
To determine the effect of RIPC of the upper limb on the inflammatory response during human endotoxemia (infusion of LPS), as well as the additional effect of 7-day RIPC compared with single-dose RIPC.
Primary Objective: - to evaluate the pharmacokinetic (PK) parameters (AUC0-t, AUC0-inf, Cmax, C24hr, Tmax, and apparent t*) of MK-3682 and its circulating metabolites (IDX20664 and IDX23267), MK-5172, and MK-8742 following administration of two…
The aim of our pilot intervention study is 1) to describe the effects of lactic acid-containing vaginal douching on the vaginal microbiota dynamics using novel molecular laboratory methods.2) to describe the effect of lactic acid-containing vaginal…
OT population excludes patients lost to follow-up, or that discontinued DTG for reasons of intolerance or toxicity. ITT = all patients that took at least 1 DTG tabletPrimary objective:* To evaluate the efficacy of DTG monotherapy in maintaining…
MK-1439 is a promising NNRTI to be used in combination with other antiretrovirals (ARTs) for the treatment of HIV infection. It is a potent inhibitor of HIV-1 replication in vitro and is active against both wild type virus and most common NNRTI…
The purpose of this study is to test how well a new vaccine works to protect against shingles in people after they have received a transplant with their own blood stem cells.
To determine the efficiency, safety and health care costs of a strategy using routine nebulisation of mucolytics and bronchodilators four times daily, with a strategy of nebulisation on a strict clinical indication only, in mechanical ventilated…
The primary objectives of this study are:• To evaluate the safety and tolerability of GS-9620 in subjects with chronic hepatitis B (CHB) infection currently being treated with oral antivirals (OAV)• To evaluate the efficacy of GS-9620 at Week 24…
The Primary Objectives are:(1) To evaluate the efficacy of MK-5172 in combination with MK-8742 as assessed by the proportion of subjects achieving SVR12 (Sustained Virologic Response 12 weeks after the end of all study therapy), defined as HCV RNA…