294 results
To study the differences in adipose tissue, liver and circulating levels of RBP4 in lean versus obese, diabetic and obese insulin, non-diabetic subjects in relation to glucose fluxes and hepatic triglyceride content
Primary: a) To asses whether there is a difference in patients with major depression and healthy controls in serotonin synthesis rates. Secondary: a) Do these rates correlate with severity of depression? b) Does serotonin synthesis correlate with…
To compare the accuracy of syndesmotic reduction on an axial CT-scan postoperatively (reflecting syndesmotic malreduction) after anatomical open reduction and fixation of the posterior malleolar fragment versus no fixation of the posterior fragment…
To evaluate exhaled breath sampling approaches and their impact on results quality. To establish if sampling procedures impact specificity and sensitivity in extracting information of interest * in our case impact of garlic/fish oil supplements on…
To compare the effect of IT dexamethasone versus IT gentamicin on number and severity vertigo attacks.To compare the effects of IT dexamethasone with IT gentamicin on hearing function, functional level scale and aural fullness.
The aim for this study is to investigate feces composition and postprandial effect, as done with oral fat loading test (OFLT), on endotoxemia (e.g. LPS and Ralstonia levels) in plasma as assessed with qPCR.
The objective of this study is to examine the vestibular system in three dimensions. To achieve this goal three experiments are performed. The EyeSeeCam video-oculography is validated with the scleral search coils (international golden standard).…
As none of the proposed experimental conditions have been executed with chronic pain patients, our main objective is to determine the sensitivity of the experimental conditions. Besides, we investigate the attention-bias for pain signals that…
This study has two goals:1. Investigate the cellular and humoral immune response of immune compromised travellers compared to the healthy traveller.2. Investigate the epidemiology of travel related infectious diseases in a population of dutch…
- The primary research objective is to estimate the prognosis of children affected by ICL. - A secondary research objective is to explore the heredity of ICL between first degree family members.
To perform a comprehensive analysis of the cellular infiltrate in lesional AD skin, using state of the art immunohistochemical techniques.
to develop a *two hit* in vivo autologous RBCs transfusion model in healthy male volunteers.
Primary Objective: Detect a difference in immunological profile between primary Sjögren*s syndrome patients in comparison with subjects from the other study groups.Secondary Objective(s): Other objectives will be the assessment tear osmolarity in…
The main objective of this study is to compare DTI findings of PPS patients with those of healthy controls. Secondary objective of this study is to correlate DTI findings with clinical data such as isometric muscle strength. Third objective is to…
In recent years, we have identified a Dutch family and performed a large number of studies which have helped us gain insight into the disorder. (MEC protocols 02/223 and 03/140, Dissertation Van Rootselaar, 2006). We want to call on family members…
The objective is to investigate whether environmental exposure to livestock farm emissions in the Netherlands poses a health risk among neighbouring residents.
First, we investigate the attention-bias for pain signals that chronic pain patients (CPP) are suggested to have. Second, we investigate whether the chronicity of pain is related to faster learning and slower *unlearning* of new associations between…
With this study we want to investigate the possible correlation between pre malignant abnormalities in the colon and inflamation of the colonic mucosa in patients with long lasting (more than 8 years) diverticular disease.Patients included will…
The end-points of this study are:1. To evaluate the prevalence of dRTA in Sjögren using a new screening test with furosemide and fludrocortisone and compare this against the gold standard test with ammonium chloride2. To determine the prevalence of…
The goal of this study is to develop a low burden, reliable and efficient screening tool for suicidal ideation and suicide risk in children and adolescents specifically addressed to capture the possible influence of medication side effects or…