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We hypothesize that PHA-022121 will be more effective in both the treatment and prophylaxis of acute angioedema attacks in patients with acquired C1-inhibitor deficiency when compared to placebo.
Tumour cell disruption by radiation generates a surplus of neo-antigens that enhances the effect of immunotherapy in solid malignancies as well as malignant lymphomas. The hypothesis is that the combination of immune checkpoint inhibitors and…
MCT is more effective than ERP, both statistically significant and clinically relevant.
Many studies described a niche (defect of the uterine scar) to be visible after a prior caesarean section (CS) by using ultrasonography. The exact moment when a niche can be visualized and the best moment to evaluate it is unknown; most studies…
Oxytocin administration leads to stronger empathic reponses and faster emotional processing.
Grasping performance of daily life grasping tasks will be improved when vibrotactile feedback about the hand opening and grasping force is provided compared to situations without vibrotactile and visual feedback.
The present study will investigate how serotonin (manipulation via ATD) modulates psychological and physiological reactions to interpersonal stimuli in individuals at risk for MDD. This is relevant for several reasons: 1. The onset, severity, and…
High-intensity stress reduces cognitive performance (visuo-spatial learning) both for immediate and delayed recall.
Study I: To assess the bioavailability of Zinc from milk (1), fortified milk (2), a supplement (3), and from raw milk (4). Study II: To assess the effect of milk on Zn absorption from intrinsically labelled rice
Budesonide does not alter the exposure of cabazitaxel in castrate resistant prostate cancer patients.
The main objective is to evaluate the efficacy and safety of phenytoin cream in patients with neuropathic pain due to CIAP
Sleep (quality and quantity) is beter in ICU patients when they are nursed in a single room compared to nursing in a 'open' ICU.
We hypothesize that the combination of LEF/HCQ significantly and safely inhibits activity of primary Sjögren’s syndrome and molecular fingerprints will allow prediction of therapy response as well as identification of pathways that confer lack of…
Use of any mask (surgical or N95) in a standard day of work for hospital staff, may result in subjective feelings of dyspnoea. These symptoms of dyspnoea do not correlate to a decreased oxygen saturation, but do correlate to baseline participant…
The percentage of curatively treatable metastatic disease after surgery for primary colorectal cancer can be increased by means of optimizing follow-up of colorectal carcinoma. Intensifying the follow-up by increasing frequency of CEA measurements…
The hypothesis of this study is that dosing everolimus 5mg twice daily(BID) instead of 10 mg once daily (QD) decreases the incidence of side effects, as a result of a lower Cmax while maintaining Cmin and AUC.