36789 results
Primary Objectives:The primary objective for this study is to evaluate the proportion of subjects who achieve SVR12 (HCV RNA < LLOQ (target not detected) at post-treatment follow-up Week 12 in subjects with GT-1b, -4 and GT-2, -3.Secondary…
So far, only a few case-studies have been tried using neurofeedback in the treatment of dementia / cognitive decline. These indicate that there are behavioural changes and emotional changes next to cognitive changes. This will be the focus of this…
The aim of the proposed research is to assess, using multimodal fMRI, both functional (BOLD responses) and structural (white matter) cerebral characteristics of the human IELT. In turn, this could provide specific novel (neocortical) targets in the…
Primary:Is the degree of pupildilation, achieved after administrating a 4.5 microliter microdrop tropicamide 0.5% equivalent to the pupildilation after a regular 30 microliter eydrop tropicamide 0.5% in healthy volunteers?Secondary: Is there a…
Primary objective:the primary objective of the study is to evaluate the safety and to define the maximal tolerated dose or the maximal administered dose of CC-486 as a single agent, in combination with CBDCA or ABI-007 in subjects with relapsed or…
The primary objective of this study is to estimate the effect of endovascular treatment on overall functional outcome after acute ischemic stroke of less than six hour duration, in patients with a symptomatic anterior circulation IAO. The secondary…
The main objective of this study is to measure the effects of the monitoring and feedback tool embedded in a Self-management Support Program on physical activity. The secondary objective is to measure the effect on self-efficacy, quality of life and…
To evaluate the accuracy and adverse events of combined use of minimal invasive optical coherence tomography (OCT) to differentiate normal tissue from (different types of) malignant tissue in kidneys.
Primary: To study the efficacy and tolerability of Midostaurin in patients with indolent or smoldering systemic mastocytosis on mediator symptom reduction.Secondary: 1) To study whether Midostaurin can reduce mast cell infiltration and 2) to assess…
To confirm the previously reported negative predictive value of urine NTproBNP for ROP in large, multi center cohort of preterm infants.
The proposed longitudinal study aims to examine1) if the onset of type 1 diabetes before vs. during puberty results in different outcomes of glycaemic control, self management, psychological functioning and diabetes-related QoL2) how the development…
Study whether a working memory training as addition to treatment as usual decreases the depression and anxiety complaints.
1. What is the complication rate of the initial antibiotic treatment strategy for acute simple appendicitis (radiological proven) in children aged 7-17 years old?
To evaluate the radiologic progression-free survival (PFS) of subjects treated with the combination of gemcitabine/docetaxel (G/D) plus MORAb-004 versus G/D plus placebo in subjects with metastatic soft tissue sarcoma (mSTS)Secondary Objectives:* To…
The aim of the vaginal morbidity sub-study is to better understand the different physical, dosimetric, biological, clinical and psychological factors and to analyse the importance of these factors for patient reported outcome on sexual functioning…
The purpose of this investigation is to determine the prevalence of device-recorded ST segment changes occurring before appropriate ICD therapies (ATP or Shock) and to define their temporal relationship to ventricular arrhythmias.
The main objectives of this study are:To obtain insight into differences in VF markers between lean and abdominally overweight / obese men.To study cross-sectional relationships between VF markers.To determine the effects of weight-loss in…
To assess if the *BasIQ* makes a standardized incision of 4 cm.
Primary Objective: Determining the effect of a patellar strap and sports tape on pain and sport participation in subjects with patellar tendinopathy. Secondary Objective(s): Determining the relationship between injury specific, sports related and…
The primary objective of this study is to evaluate the safety and tolerability of trastuzumab emtansine.