36837 results
Primary:- To evaluate the efficacy of the combination of temozolomide with vincristine and irinotecan in children and adult patients with relapsed rhabdomyosarcoma as assessed by confirmed objective tumor response.Secondary:- To evaluate the safety…
Primary: To characterize the QGE031 dose response relationship for the increase in the threshold dose of peanut protein that induces objective hypersensitivity reactions after treatment.Secondary (only key parameters): The percentage of patients…
The aim of this study is to investigate the safety and efficacy of biodegradable self-expandable stents in patients with a benign fibrotic pancreatic duct stricture due to chronic pancreatitis.
The primary objective of this study is to examine whether people with autism have an atypical sensitivity to specific visual information, and if this can explain differences between them and healthy controls in looking at faces.
Primary : - to assess the safety and tolerability of a single ascending intravenous iv infused doses of OPN-305 in healthy subjects- determination of dose and infusion time for Phase II studiesSecondary : - to determine the pharmacokinetic profile…
AKINESIS is a multi-center prospective, uncontrolled clinical study to assess the utility of a plasma NGAL test (Triage® NGAL Test) and a urinary NGAL test (ARCHITECT® Urine NGAL) in predicting worsening renal function in patients presenting with…
In the present study we aim to determine the value of microvascular resistance measurements in the acute setting to predict the occurrence of MVO in the following days, using the combined pressure-flow wire. Therefore patients with an acute MI will…
The objective of this study is to improve the understanding of subjective cognitive complaints expressed by patients with OSAS by:1. Comparing subjective cognitive complaints of patients with OSAS to healthy controls2. Studying the effect of…
To investigate the differences in facial analysis, between patients with acromegaly, being in remission, and healthy subjects, and to investigate the changes in relational proportions between these facial structures.
We will study how a memory decision comes into being and how decisions based on information that is directly available to the senses may or may not differ from decisions based on information in memory. The neural correlates of perceptual decisions…
The objective of this research is to study satiation effects of aroma-taste interactions in dairy based products.
The aim of the current study is to examine the (cost)effectiveness of Mindfulness Based Stress Reduction (MBSR) in comparison with treatment as usual for patients with lung cancer and their partners.
Determination of non-inferiority of volume-reduced platelet concentrates compared to plasma platelet concentrate in terms of recovery. To assess safety (bleeding and thrombotic complications, and adverse transfusion reactions) and transfusion…
The primary objective of this study is to gain more knowledge about the mean and the distribution of mitochondrial oxygen tension (mitoPO2), the mitochondrial oxygen consumption (mitoVO2) and the affinity for oxygen of mitochondrial respiratory…
We will identify factors that interfere with the beneficial effects of exercise on the vasculature in T2DM.
Primary objectives: • To determine the feasibility of LV septum lead placement by transvenous approach through the inter-ventricular septum in patients with sinus node dysfunction (SND) and structurally normal hearts, as well as in patients with…
The overall aim of the DALI study is to identify the best available measures to prevent GDM in an ongoing pregnancy, to provide a cost-benefit calculation of GDM prevention for health care systems, and to establish a pan-European cohort of mother-…
Primary objectiveTo investigate whether the addition of preoperative radiochemotherapy to the standard treatment, consisting of explorative laparotomy, pancraticoduodenectomy if possible, followed by adjuvant chemotherapy, improves the overall…
The objective of this study is to establish the effects of transfer of learning in children with upper limb deficiencies after practising with an upper limb prosthetic simulator.In children, transfer of learning effects have hardly been studied. The…
The purpose of this study is to investigate the clinical effectiveness of a self management group intervention for stroke patients with social reintegration problems and their partners compared to a control group education intervention. The main…