12513 results
Primary Objective: The treatment result expressed as the proportion of successful treatments per treatment arm (successful = VUR <= grade 1 and/or no urinary-tract infections 6 months after the operation) does at least not show a significant…
To improve the response rate to treatment of severe acute GVHD (grade II-IV with gut involvement ) by adding infusion of Mesenchymal Stroma Cells to standard high dose prednisolone.
Primary objectivesFor part A of the study: -To determine the feasibility of Clofarabine when given at three possible dose levels together with standard induction cycles I and II in patients with AML/ RAEB with IPSS>=1.5 in a prospective…
Primary Objective: (1) To study the efficacy of low volume high-intensity resistance training for improving glycemic control in patients with T2DM. Secondary Objectives: (2) To study the feasibility of low volume high-intensity resistance training…
To determine the efficacy and safety of laser therapy in diabetes patients with risk factors for developing diabetic foot complications.
The primary objective is to demonstrate that detoxification of benzodiazepines in high-dose benzodiazepine dependent patients using continuous subcutaneous infusion of flumazenil is feasible and safe.Secondary goals of the study are to explore 1)…
Identify DNA methylation markers suitable for sensitive and specific plasma-based detection of advanced colorectal adenomas.
The main objectives of this study are to (I) investigate characteristics of children and adolescents with CD and/or ODD in comparison with typically developing (TD) controls and (II) examine subtypes of aggression on the behavioural, cognitive,…
Primary objective *To determine Maximum Tolerated Dose (MTD) of TH-302 combined with chemoradiotherapy (23 x1.8 Gy in combination with Carboplatinum and Paclitaxel) in patients with distal esophageal or esophago-gastric junction adenocarcinoma, and…
To provide subjects who have completed participation in a Phase 2 or Phase 3 trial continued access to therapy and to evaluate the long-term safety and tolerability of leuco-methylthioninium bis(hydromethanesulfonate) given in flexible doses of up…
The primary objective is to evaluate the difference in 68Ga-exendin tracer accumulation in the pancreas of patients with and without complete resolution of T2DM after RYGB by quantitative analysis of PET images.
In this study, the following questions will be answered:1. Does larval therapy accelerate wound healing?2. Do single larval secretions accelerate wound healing?3. Is the bacterial load in the wound reduced during larval therapy or is the microbiome…
Primary Objective: The objectives of this study are to assess lumen, scaffold, vessel dimension, malapposition and tissue coverage as assessed by quantitative angiography, intravascular optical coherence tomography and intravascular ultrasound…
To detect ophthalmic differences between patients and controles. To detect (early) changes in the retina in (pre)symptomatic RVCL disease carriers, in order to find a *biomarker* for disease stage and progression.
The objective of this study is to demonstrate the influence of pectus excavatum on the anaerobic threshold during exercise. This could be an objective measurement of exercise intolerance. An objective measurement of exercise intolerance can later…
We study the efficacy of the retractor sponge in laparoscopic colorectal surgery to reduce hospital stay in patients operated for a malignancy. Secondary objectives are duration of surgery, blood-loss,use of diuretics as volume therapy (during…
The main objective of the present project is to assess the impact of gender, physical inactivity, obesity, and bariatric bypass surgery on basal and postprandial muscle protein synthesis rates. This will be investigated by means of three different…
A study on extent-related outcome and complications for degenerative cervical spinal disease has not yet been performed. Results of this study may form the basis for a guideline regarding the extent of fixation in degenerative cervical spinal…
The primary objective is investigating the effectiveness of *Mindlight* in treating (sub)clinical symptoms of anxiety in children who are diagnosed with an autism spectrum disorder. The secondary objective is to examine the factors that moderate and…
In this study, we have the following research objectives:1. To examine if NF, by applying the above mentioned AA-protocol, is an efficacious treatment for major depressive disorder. We will conduct a RCT in which active NF will be compared to sham-…