373 results
The primary objective is to get a comprehensive insight in the role of body composition features in RCC, and how these are related to patient-, tumour- and lifestyle-related factors, circulating biomarkers, and recurrence and survival.The research…
To assess real world experience with HeartMate PHP post CE Mark approval in supporting patients who are hemodynamically unstable, or at risk of being hemodynamically unstable, while undergoing complex percutaneous coronary interventions (PCI).
The purpose of the study is to examine how the Minicare I-20 fits into the ambulance workflow. Relevant process data of the ambulance workflow was collected (stage 1) looking specifically into chest pain patients. This second stage will focus on…
Primary Objective: To investigate the differences in microbiota composition in the upper GI tract between lean and obese subjects. Secondary Objectives: To compare the total bacterial count measured by qPCR in SI samples of lean versus obese…
The aim of this pilot study is to validate potential biomarkers which diagnose patients who will benefit from asthma treatment with macrolide therapy by using non-invasively collected body fluid specimens. Th1/Th2/Th17 patterns in patients suffering…
The primary objective of this study is to review the incidence of pelvic organ prolapse after laparoscopic hysterectomy compared to vaginal hysterectomy.
To see whether C. burnetii is able to induce epigenetic changes in monocytes, resulting in a more distinct pro-inflammatory response to re-stimulation with viral particles, to see whether these changes are present in circulating monocytes of QFS…
In this study we want to investigate the CD80/CD86 region whether polymorfism in the 3q21 region of the DM2 population are associated with a high prevalence of autoimmune diseases. If this is indeed the case, this will help our insight in the CD80/…
In this single center cohort study the primary objective is to assess minimal residual autoimmunity (MRA) in RTX treated AAV patients. The primary objective is to routinely assess the composition of the memory B-cell and plasma cell compartment…
Primary Objective: To investigate whether differences exist in muscle function, muscle energy metabolism and cardiorespiratory fitness in CML patients with muscle complaints, compared to CML patients without muscle complaints, and controls (non-CML…
To determine which costimulatory and co-inhibitory molecules are expressed on tumor-infiltrating lymphocytes (TIL) derived from patients with CRC (including metastasized CRC), and to study the effects of targeting these molecules on their function…
Lynch-related tumors mostly develop in the ascending right side of the colon (70-85%). Strikingly, it was recently discovered that dense bacterial biofilms and invasive bacteria occur in the colonic mucosa of 87% of right-sided colorectal cancer (…
1. We will perform an exploratory study using whole exome sequencing (WES) on SS MALT lymphoma samples to pick up specific gene mutations enriched or exclusively present in salivary MALT lymphoma in SS patients.2 .We will investigate the relation…
to determine the prevalence and significance of chronic nephrotoxic effects of cisplatin therapy by 1) identifying patients with chronic cisplatin nephrotoxicity and 2) reviewing their QoL. Eventually, this could improve care in these patients
To analyse serum sodium concentration, serum osmolarity and arterial bloodgas at different times before and after administration of HTK solution, to get more insight of the impact of this solution on these biochemical parameters and to improve our…
Primary Objective: to determine if lactate can be continuously and reliably measured by microdialysis in subcutaneous tissue in healthy volunteers
Hypothesis: gaseous signaling molecules influence placental vasomotor activity to compensate for hypoxemia. Metabolites of these vasoactive molecules can be found in the blood and urine and can indicate whether this (compensatory) mechanism is used…
The objective of this study is twofold. First objective is to determine the reproducibility and inter-rater reliability of Perfusion Angiography. The second is to investigate the predictive value of Perfusion Angiography for wound healing in…
Biobanking of testicular biopsies from azoospermic men undergoing testicular sperm extraction (TESE)
Biobanking of a testis biopsy from men with azoospermia who undergo a TESE procedure to allow investigation for understanding the etiology of male infertility, research about normal and aberrant male gamete formation in its natural environment of…