84 results
To study the validity and usefulness of three immunological assays to improve knowledge on the course and diagnosis of sesame seed allergy in sesame seed allergic patients with proven anaphylaxis. In the first place, the CAP inhibition assay is used…
Objective: Main objective of this study is to compare the area under the MPH saliva concentration versus time curve (AUC) following ingestion of immediate and sustained release formulations of MPH in children with ADHD. Secondary objectives are: 1.…
To detect high-risk pathogenic mutations in germline DNA of children with childhood cancer that are suggestive of genetic predisposition, using NGS-based whole-exome sequencing, resulting in novel targets for future functional and translational…
The aim of this protocol is to invite the NeuroIMAGE cohort once more for a follow-up investigation and collect phenotypical, cognitive, and MRI data. This design offers the opportunity to examine by means of longitudinal phenotypic, cognitive, and…
Long-term evaluation of thyroid disorders ( TSH elevation and the occurrence of thyroid nodi/carcinoma) in survivors of childhood NBL who received KI, methimazole and thyroxine as thyroid protection during 131I-MIBG exposure. Investigation of the…
To assess the one-year (cost)effectiveness of self-management support via an internet-based service in addition to usual care as compared to usual care alone in a pragmatic trial in patients with severe asthma who are referred for a pulmonary…
Aim is to determine the usefulness of the Autism Quotient as a screener for autism spectrum disorders in 15-18 years old boys. Possibly comorbidity like conductdisorders lessen the usefulness of the autism qotient as a screener because some boys…
Aim: To investigate the performance of the new ESPGHAN diagnostic criteria for celiac disease in practice in different European countries.Primary aim: To evaluate whether the omission of biopsies in selected pediatric cases does result in certain…
Primary: To compare the efficacy of aripiprazole with placebo in the suppression of tics in children and adolescents (7-17 years) with a diagnosis of Tourette*s Disorder. The primary efficacy measure is change from Baseline to endpoint (Week 8) on…
The first objective of our study to explore the relation between pro- and anti- inflammatory markers (hsCRP, TNF-α, IL-1ß, IL-6, IL-8, leptin, adiponectin) and BMI z-score in obese children participating in our intervention programs (AanTafel!, de…
Main: to examine how treatment response and non responder profiles relate to contemporary dichotomized forms and correlates of aggressive behaviour (i.e. pro active vs. reactive, cognitive distortions), location where the treatment is offered,…
The primary aim of this study is to examine whether impulsivity in adolescents with ADHD is related to delay aversion or to alterations in reward sensitivity, and to understand the neural pathways underlying impulsive behavior. We will (1) compare…
Since this cohort is at risk for many developmental problems, further follow-up on this cohort is warranted. We especially want to examine growth, pubertal development, and the neurocognitive- and behavioural development. Since we have many…
The overall aim of this study is to find objective and sensitive markers to predict short term and long term food challenge outcome. Primary Objectives: - Can we predict (severity of) short- and long-term food challenge outcome with clinical and…
Investigate how physical fitness and activity evolve over time in paediatric burn patients, also in relation to function.
Evaluate the diagnostic value of the Basophil Activation Test in determining the presence of peanut allergy in children.Domain: Children with suspected peanut allergyDeterminant: The Basophil Activation TestOutcome: The presence of clinically…
To evaluate the impact of electroencephalographic Narcotrend* Index (NI) monitoring on the speed of emergence and recovery from PPS for PGE.
1) Follow-up study of project 2011_371:To determine whether the 27 children found in this study actually had a central hypothyroidism, by complementing the existing data with details from the medical records. The data used in the first study were…
The aims of this study are to reduce early symptoms of severe psychiatric disorders. 1.Developing a intervention which focuses on the reduction of early symptoms of psychiatric disorders by combining elements of existing methods, namely an…
We hypothesize that cardiovascular risk factors may already be present during childhood in CAH patients. Therefore, we will perform a cross-sectional study in CAH patients aged 1-16 years evaluating blood pressure, lipid profile, insulin sensitivity…