1634 results
To compare tumor [11C]erlotinib pharmacokinetics in NSCLC patients with and without erlotinib therapy. Also, to assess the relationship of venous sampling versus arterial, of tumor [11C]erlotinib uptake and blood flow with and without therapy, and…
1. Discribe the normal development of mastication in healthy children aged between 6 and 48 months by using the Mastication Observation and Evaluation (MOE). Which oral motor behaviours occurs?2. Determine the differences in mastication between…
-The primary objective is to compare the CYP2D6 phenotype, determined by DM-BT in frail and non-frail elderly (by using Fried definition).-The secondary objective is to correlate individual parameters of frailty (e.g. grip strength) with CYP2D6…
This study is dedicated to obtain accurate broadband (400 - 1830nm) diffuse reflectance spectra of human nerve tissue in vivo (which knowledge creates possibilities to design useful imaging devices).
Primary: To compare the efficacy of aripiprazole with placebo in the suppression of tics in children and adolescents (7-17 years) with a diagnosis of Tourette*s Disorder. The primary efficacy measure is change from Baseline to endpoint (Week 8) on…
Primary:To assess after administration of a single oral dose of 75 mg S 38844 containing 55 *Ci (2.035 MBq) of [14C]-S 38844:* The excretion balance of total radioactivity;* The pharmacokinetics of total radioactivity in blood and plasma;* The…
Primary objective: association between pharmacokinetic modeling of [18F]FLT PET and simplified measures during treatment with gefitinib in patients with NSCLC to validate the use of simplified measures during treatment with gefitinib of…
The study aims to answer the following questions: 1) What is the effect of Retigabine on cortical excitability measured by TMS ? (primary). 2) To what extent are changes in excitabilty meausred with TMS related to seizure control ? (secondary).
The primary objective of this controlled clinical trial is to evaluate the clinical effect of systemic amoxicillin plus metronidazole therapy in conjunction with initial non-surgical treatment of peri-implantitis. The secondary objective is to…
The primary objective of the study is to validate the use of a reference tissue model and an image derived input function for the quantification of estrogen receptors in the human brain, by [18F]FES PET. The secondary objective is to determine…
Long-term evaluation of thyroid disorders ( TSH elevation and the occurrence of thyroid nodi/carcinoma) in survivors of childhood NBL who received KI, methimazole and thyroxine as thyroid protection during 131I-MIBG exposure. Investigation of the…
Our primary objective is to set up the Human Rhinovirus (HRV)-model in our centre, using HRV serotype 16 (HRV-16). Secondary objectives:1. To determine the incubation period of HRV-16 infection.2. To determine the effects of HRV-16 infection on cold…
Objectives of the study: Project 1 - To assess early adaptive deficits in a multicentre cohort of mild to moderate TBI patients and their relation to outcome. Project 2 - Early intervention study of Cognitive Behavioural Therapy (CBT) to assess…
To determine the dose-limiting toxicities (DLTs) and maximum tolerated dose (MTD) of MK-8353 administered orally in combination with other agents to adult subjects with advanced tumors and to determine the recommended Phase 2 dose (RPTD) of MK-8353…
Primary: 1. To demonstrate migration of circulating white blood cells into atherosclerotic lesions in subjects with atherosclerotic disease via quantification with SPECT.Secondary: 2. To evaluate the relation between FDG-PET signal (reflection of…
The aim of this study is to find cable operation forces and displacements which can be perceived and controlled best by a prosthetic user.
Primary:* Study the influence of sleep on motor performance and cognitive flexibility in PD patients.* Compare and describe in more detail, the differences in the influence of sleep in patients that report to experience SB and those who do not.…
The main objective is to investigate mechanical alternans and MTWA in TAVI patients to demonstrate a possible correlation between these two phenomena.
Primary Objective: The main objective is to gain insight into the functional and structural neural correlates of success in foreign language learning. To this end, fMRI and DTI data will be acquired together with behavioral responses from healthy…