138 results
The aim of this study is to investigate if there is a correlation between the clinical phenotype (defined as age of first bleeding) of patients with haemophilia A and the results of the whole clotting assessment (TMETP + T-TAS).The results will…
AdOpt CRT is designed to compare indices of cardiac function at device settings optimized using an investigational Adaptive CRT (aCRT)algorithm versus CRT with nominal programming. The comparison will be performed during rest and submaximal exercise…
The primary objective is to assess whether renal denervation added to usual care compared to usual care alone reduces BP (office based BP and 24-h ambulatory BP-monitoring) both in subjects with a SBP level above 160 mmHg as well as subjects with a…
Core StudyPrimary objective• To compare the efficacy of E5501 (in addition to standard of care) to eltrombopag (in addition to standard of care) for the treatment of adult subjects with chronic immune thrombocytopenia (idiopathic thrombocytopenic…
To explore, whether the magnitude of the effect - in terms of progression free survival at one year - due to the addition of SABR after chemotherapy for selected patients with metastatic disease from solid (non-germinoma) tumours might justify a…
To report on (the age-dependency of) the long-term effect(s) of chronic SSRI treatment during adolescence or adulthood on the outgrowth and function of the 5-HT system, using state-of-the-art Magnetic Resonance Imaging (MRI) techniques and other,…
Primary: to study the frequency and characteristics of fatigue and cognitive disorders after minor stroke. Secondary: to gain more insight in the aetiology of post-stroke fatigue and evaluate the impact of post-stroke fatigue on personal and social…
Our aim is to determine the effect of APO* on activity and volume of the hippocampus, a core structure of Alzheimer pathology, at a young age. Specifically, we aim 1) to determine the effects of APOE e4 on hippocampal activation in the young general…
The objective is to gain insight into the efficacy of bright light therapy for chronic sleep onset insomnia in children with ADHD, and to evaluate whether amelioration of the sleep problem results into improved cogntion and behavior as well.
Objectives1.3.1 Primary ObjectiveCompare the efficacy of BMS-945429 versus placebo for induction of clinical remission (defined by an absolute Crohn*s Disease Activity Index [CDAI] score < 150) at Week 8 (IP-57).1.3.2 Secondary Objectives•…
1) Does FSAP activation in plasma of HAE patients contributes to bradykinin formation? 2) Study the inhibitory efficacy of c1-inhibitor towards kallikrein and FSAP towards bradykinin formation in a endothelial cell-based system. 3) test the efficacy…
Our aim is to optimize treatment for patients with moderate to severe psoriasis by creating evidence for the optimal dose of MTX (on short- and long-term) with the largest disease reduction and the least side effects.
The primary objectives of our study are:1. to compare the diagnostic performance of coronary CTA with coronary MRA to detect significant coronary stenoses (> 50% reduction in lumen diameter), in patients with a range of coronary calcium…
The purpose of this clinical investigation is to verify the efficacy and safety of the CVRx Neo System in subjects who qualify for the implantation for a Baroreflex Activation Therapy System compared with subjects who do not receive this device.
Objectives: The objective of the study is to observe the sorbitol clearance and compare this to ICG clearance in different circumstances of normal and compromised liver blood flow.
By making this design study we wish to contribute to profound research on percutaneous gastrocnemius lengthening for for children with an equinus contracture and prevent publication bias for this open-labelled randomized trial.
2.1 Primary objectiveTo assess the rate of no progression (NPR) at 8 weeks following treatment with the combination of gefitinib and fulvestrant in EGFR mutated patients who failed previous treatment with reversible EGFR TKI*s (gefitinib or…
The primary objective of the study is to evaluate whether the addition of LABA to ICS therapy (FSC) is non-inferior to ICS therapy alone (FP) in terms of the risk of serious asthma related events (asthma-related hospitalization, endotracheal…
Aim of the present study is to investigate whether LIFT or TAFR is the preferable treatment for high transsphincteric fistulas-in-ano of cryptoglandular origin.
The Purpose of this study is to compare the surgical treatment of flail chest with the non-operative treatment regarding complications.Hypothesis: Surgical stabilization of rib fractures in flail chest results in fewer respiratory complications,…