86 results
zie K1
BAY 63 2521 is a stimulator of the soluble guanylate cyclase (sGC) and is intended for the treatment of cardiovascular diseases, especially pulmonary hypertension (PH).To assess the longterm safety and tolerability of oral BAY 63-2521 in patients…
Primary objectiveThe primary objective of this trial is to identify the optimal effective dose of AS900672-Enriched to induce ovulation in oligo-anovulatory infertile women.Secondary objectives* To demonstrate that the clinical pregnancy rate of the…
PRIMARY• To determine the efficacy on study Day 28 of the IT-combination in inducing a clinical response in patients with severe acute GVHD refractory to first line therapy with intermediate dose corticosteroids. SECONDARY• To evaluate the overall…
To conduct a randomised trial to test the hypothesis that the experimental condition, i.e. the intervention*Gezin aan bod*, is superior to 'care-as-usual' in exerting a positive effect on a number of the risk factorsfor problematic…
In the current proposal we hypothesize that vulnerability to stress is a non-specific risk factor for developing either schizophrenia or MDD. Increased stress sensitivity is hypothesized to be related to reduced prefrontal functioning, leading to…
The objective of this observational study is the safe introduction of clinical applied IVM in The Netherlands. During this study, the number and quality of the oocytes and embryos will be studied as well as pregnancy development. Emphasis will be on…
Goal of the study is to establish evidence on cognitive biases in a high risk population and on the longitudinal impact of such biases. We hypothesize that CPAD*s show biases in their information processing when compared to control children. We…
The aim of this study is to investigate whether DWIBS may be an appropriate technique for colorectal cancer screening.
Study ObjectiveTo determine whether alprazolam, a registered anxiolytic non-selective benzodiazepine, can reduce the autonomic temperature increase induced with social stress in healthy men. Secondary objectives are to determine whether alprazolam…
Primary objective is to evaluate the HIV-1 specific immunity after two vaccinations with the HIV-1 specific recombinant vaccinia vaccine NYVAC-B, compared to placebo. Secondary objectives are the evaluate of the change in plasma HIV-1 RNA in…
Compare two surgical techniques for treatment of posterior CECS.
The primary objective is to study the effect of a 16-week treatment with a PPAR-* agonist versus placebo on effectiveness of subsequent standard treatment with PEG-IFN and RBV, measured as SVR, in previously non-responders or relapsers with CHC…
which particles can be found in induced sputum of construction workers? What is the composition, size and concentration of quartz particles measured in sputum of the different exposure groups?
To test if viewing a medical consultation on video leads to comparable psychological and physiological responses to the communication as being a patient in that consultation.
The objective of the study is two-fold:First, we want to improve the design of the study for future extension, by critical evaluation of the efficacy, the instruments used and the outcome measures. Second, we want to assess the cognitive and…
1. How functions the dopaminergic neurotransmission in adult patients with VCFS who are functioning on an intellectual level of moderate to severe impairment (IQ < 55) by a) a strong cognitive decline or b) a premorbid level of functioning.2…
We would like to investigate the efficiacy of the treatment of Trigger Fingers by means of a reliable, randomised, controlled, prospective multi-center trial at a large-scale with a long term follow-up. After completion of the trial we will be able…
To scrutinize the role of OT in human social-emotional behaviour and gain insight in the neurobiological mechanism by which the peptide exert their effects.
The aim of the study is to investigate the effects of atomoxetine on driving performance compared to placebo in 30 adult patients with ADHD. An auditory oddball paradigm will be presented and EEG will be measured during driving to gain insight in…