247 results
To identify risk factors for injuries in novice runners, and to identify risk factors for specific injuries.Secondary Objective(s): 1. To determine the incidence of running related injuries in novice runners2. To describe the health benefits of the…
To detect the differences in the length of the urethra in healthy volunteers and in men after laparoscopic radical prostatectomy.To detect the degree of erectiel dysfunction before and after laparoscopic radical prostatectomy.To detect the cause of…
Primary Objective: Using task fMRI to assess differences in the brain activation during evaluative social feedback and script-driven emotional imagination between participants with BPD and healthy controls. Moment-to-moment self-esteem and mood…
To determine the direct effects of morning light intensity on postprandial glucose and lipid metabolism and metabolic gene expression in adipose tissue.
To determine the frequency of MBL and FCN SNPs in patients with a history of a proven gram-positive bacteremia, compared to patients without such history. A secondary objective is to determine whether extracorporeal circuits, used in cardiothoracic…
In this study we aim to investigate whether infusion of intestinal microbiota from lean (vegetarian) donors has differential effect on choline (d6-labeled choline) and carnitine (d3-labeled carnitine) metabolism and macrovascular inflammation (18F-…
Primary Objectives:- Evaluate changes in the immune system upon exposure to FVIII in patients with severe hemophilia A - Identify immunologic predictors of FVIII inhibitor development or tolerance
The primary aim of this study is to validate the paradigms designed to investigate the effects of social stress and reward on in healthy individuals. This will allow us to evaluate and optimize the experimental paradigms in terms of their design,…
Primary objective:To assess the two-year prevalence and incidence of clinical relevant arrhythmias in drug-resistant epilepsy.Secondary objective:To assess whether the recorded cardiac arrhythmias are related to epileptic seizures (subjectively from…
Determining the effect of long-term weight loss after bariatric surgery on:- striatal dopamine D2/3 receptor availability - behavioral parameters- plasma hormones, metabolites and peptides involved in appetite regulation, and glucose metabolism
to develop a *two hit* in vivo autologous RBCs transfusion model in healthy male volunteers.
The overall aim of our study is to evaluate the management of suspected uncomplicated UTI in women presenting in primary care through use of a novel point of care test (POCT, Flexicult). This study is being carried out in 4 European networks: Wales…
The following research questions were formulated:• Does blood group P status (presence or absence of the 42C>T-SNP) correlate to GB3 content on fibroblasts and white blood cells of healthy controls?• Does blood group P status correlate to (…
The primary objective is to study the course of muscle (fiber) atrophy in elderly males and females with a fall-related hip fracture or elective hip surgery and the influence of additional nutritional support during hospital admission. Secondary…
To investigate whether pRDN leads to a change in renal blood flow
To investigate the risk of deeath and incident (cardio)vascular disease in patients with a TIA or stroke aged 18-50 yearsTo investigate the riks of cognitive impairment and (vascular) dementia in patients with a TIA or stroke aged 18-50 yearsTo…
The overall aim of this study is to investigate interoceptive conditioning of fear and it*s generalization in both panic/anxiety patients and healthy control subjects. Therefore we have three specific objectives. The first objective is to replicate…
(i) To compare the DBF response to capsaicin between cystinosis patients, homozygous and heterozygous for the 57-kb deletion, and matched controls.(ii) To compare the skin sensitivity response after capsaicin application between cystinosis patients,…
1) To investigate the differences in lipid content of the plaques after placement of a Stentys self-apposing stent. 2) To investigate whether there is a correlation between the decrease lpid-core content and the increase in cardiac biomarkers (…
The primary aim of this observational study is to determine the occurrence of exercise-induced left ventricular diastolic dysfunction (LV-DD) in symptomatic COPD patients with a normal echocardiography at rest. And, secondly, to study the…