72 results
The detection rate of the ICG method to identify the SLN in breast cancer patients is not inferior to the standard 99mTc method.
Postoperative NRS pain scores in the breast after BCS are lower in women who receive a preoperative PECS II block than in women who receive a sham block.
As this is an explorative design, no formal hypothesis is made. However, our sample size is based on a difference of 2.5% or more in cumulative incidence of serious infections when continuing IA, hypothesizing that patients who continue their IA in…
To compare stent expansion after plaque modification by IVL or balloon predilation in severely calcified coronary lesions assessed by optical coherence tomography (OCT).
Is care as usual (CAU) with adjunct evidence-based prescription of exercise more effective than CAU alone in reducingdepressive symptoms in patients with major depressive disorder in the specialised mental health service setting?
Investigate the effects of 7 (+-1) days of of mono- and combination therapy with the SGLT2 inhibitor empagliflozin (10 mg QD) and RAS inhibitor losartan (50 mg QD) on renal hemodynamics, (glomerular filtration rate (GFR) / effective renal plasma…
2.1 Primary ObjectiveDescribing the association between Handscan optical scores, markers of inflammation (levels of CRP, serum IL-6) and clinical swollen joint score in three treatment groups with different pharmacokinetic modes of action for RA…
To study the effectiveness of low-dose rivaroxaban with aspirin in improving endothelial function in patients with symptomatic or stable PAD.
We hypothesize that treatment of RA can be individualized by taking into account the presence of autoantibodies and quick response to glucocorticoids and JAK inhibitors. Therefore, the aims of this randomized controlled trial are: 1. To compare…
The objectives of the study are to describe:1. The efficacy of the Edwards Cardioband Mitral System in improving mitral regurgitation, functional status, and quality of life.2. The safety of the Edwards Cardioband Mitral System.
Primary objective: To reduce clinically relevant respiratory tract infections (including COVID-19) ind community dwelling older persons during the pandemic of SARS-CoV-2. Secondary objective: To reduce disease severity, the duration of hospital…
The primary objective of this study is to examine clinical and radiographical parameters when executing:- adjuvant antibiotic therapy versus no antibiotic therapy in the resective surgical treatment of 0-, 1- and 2-wall bone defects due to peri-…
We aim to investigate the renal hemodynamic effects of empagliflozin in people with either preserved or impaired renal function with T2DM and people with impaired renal function without T2DM, all with and without adenosine blockade.
The aim of the current study is to determine whether a *liberal* strategy of maintaining Hb concentrations above 9 g/dL would result in a different neurological outcome when compared to a *restrictive* approach to red-cell transfusion to avoid…
The primary objectives of this study are:· To assess the time to first exacerbation of COPD, measured from the time of randomization The secondary objectives of this study are:· To evaluate the improvement of quality of life by Saint George*s…
To assess the safety and effect of edoxaban in Chil-Pugh B cirrhosis.
To further research nintedanib PK and correlate them with clinical parameters and toxicity. Results could be used to optimize treatment of nintedanib in the future by dose individualization based on patient*s characteristics or therapeutic drug…
To investigate the effect of the ARB valsartan in comparison to placebo on the occurrence of one of the following items, within 14 days of randomization:1) ICU admission; 2) Mechanical ventilation; 3) Mortality.
To investigate if a high loading dose of 2 grams paracetamol has a beneficial effect on pain sensation or has an opioid-sparing effect in patients with pain in the Emergency Department
To determine whether polystyrene sulfonate has an effect on exposure of amitriptyline, when taken simultaneously, compared to amitriptyline taken alone in healthy volunteers, expressed in Cmax and AUC0-8h.