733 results
The aim of this study is to demonstrate that a single dose of rabies vaccine can induce an equally rapid and adequate anamnestic antibody response as 3-dose PrEP to revaccination five years later.
Obtain insight into the (difference in) pertussis-specific immunoglobulin G (IgG) levels in the first three months of life between infants whose mothers received a pertussis vaccine (Boostrix) during pregnancy in comparison to infants whose mothers…
PRIMARY OBJECTIVE: -To assess the antibody response after mRNA (Pfizer, Moderna) SARS-CoV-2 vaccination in children with cancer SECONDARY OBJECTIVES: To assess in children with cancer after SARS-CoV 2 vaccination: - durability of…
As this is an explorative design, no formal hypothesis is made. However, our sample size is based on a difference of 2.5% or more in cumulative incidence of serious infections when continuing IA, hypothesizing that patients who continue their IA in…
A decrease in the incidence of central line-associated bloodstream infections in the investigational study group, compared to the control group.
To assess the prevalence of LDL-C >1.8 mMol/L in a subgroup of very high risk patients with ASCVD, who remain at a very high-residual risk for ACS, despite treatment with high-intensity statins in combination with ezetimibe. This subgroup of…
The effect of mebeverine on abdominal pain intensity and frequency in children with irritable bowel syndrome or functional abdominal pain – not otherwise specified will be effective.
Postoperative recurrence of CD (Crohn's disease) is very common in patients having undergone bowel resection, and often leads to further bowel resection. Postoperative recurrence is frustrating to both the physician and patient, and thus an…
To investigate the pharmacokinetic profile of magistrally compounded CDCA capsules.
We hypothesise that antibiotic-corticosteroid eardrops are non-inferior to oral antibiotics in resolving ear pain and fever at day 3 (72 hours after randomisation) in children aged 6 months to 12 years visiting their GP with AOMd and either ear pain…
To investigate whether Envarsus® leads to a significant reduction in new onset diabetes, chronic kidney disease and new onset hypertension.
We hypothesize that benesco TM reduces symptoms, esophageal acid sensitivity and permeability in patients with reflux symptoms
"Objective: The primary objective is to evaluate if %EWL after LSG as bariatric therapy is equal or, within an acceptable margin, inferior to LRYGB. Secondary objectives are to evaluate QOL, cure /improvement of obesity related co-morbidity (i.…
The proportion of successful patients, defined as an improvement in LARS category, will be 25% larger in the experimental group than in the control group (in which 10 % improvement is assumed).
MOCA using Flebogrif is not inferior to EVLA for the treatment of GSV insufficiency.
The rationale of this study was to investigate the alteration of colonic motor patterns in the early postoperative stage and between patients with no or minor LARS-symptoms (LARS-score < 30) compared to patients experiencing major LARS…
To investigate the effect of various dietary interventions and co-administration of subcutaneous semaglutide on the pharmacokinetics of alectinib in NSCLC patients.
IV sildenafil is superior to iNO for the treatment of pulmonary hypertension in CDH newborns and should be considered as the drug of first choice in the future
Postoperative NRS pain scores in the breast after BCS are lower in women who receive a preoperative PECS II block than in women who receive a sham block.
Objectives: 1) to evaluate the effectiveness of the e-CBT-i “i-Sleep” compared to a waiting list condition on sleep efficiency at 3, 6 and 12 months in ACC. 2) to assess the effects of eCBT-I on secondary outcomes: fatigue, quality of life, chronic…