46 results
In this phase I/II clinical study will assess the safety, effectiveness and homing of asCTMP, namely autologous mesoangioblasts, that will be injected 3x intra-arterially in right lower leg via catheter in 5 indivuals that carry the m.3243A>G…
We want to study the effect of glutamine on duration of mechanical ventilation and lenght of stay in ICU or hospital.With the availability of a Point of Care (POCT) measurement of plasma glutamine level a measurement can be performed short after the…
The goal of the present study is to investigate the effect of head cooling after kickboxing matches on cognitive functioning amongst both amateur and professional kickboxers. Based on the above mentioned studies, it is hypothesized that head cooling…
The primary objective is to determine the efficacy of MagnetOs microstructured BCP granules in inducing adequate bone quantity and quality to support endosseous dental implants in the two-staged maxillary sinus floor augmentation procedure.…
The primary objective of this study is to determine the efficacy of vitamin D supplementation on the severity of PN in patients with multiple myeloma.
This study aims at establishing the influence of sampling site on the variability of ACT measurement at the end of coronary angiography or PCI.
The aim of our project is to perform a novel mass screening to detect CD in 12 months-4 years old children who visit the YHCCs in a well-described region in the Netherlands, to show that it is feasible, efficient, cost-effective and well accepted by…
Primary objectiveThe primary objective of this study is to evaluate the efficacy of bimekizumab in subjects with moderate to severe HS.Secondary objectiveThe secondary objective of this study is to assess the safety, tolerability, immunogenicity,…
The main objective of this pilot study is to evaluate feasibility, experienced effects and side effects of LLLT, in relation to the administered dose to be able to detect an appropriate dose (intensity of laser) in patients with non-allergic…
The primary objective is to identify additional genetic loci associated with skin fluorescence in patients with type 1 diabetes Mellitus. Secondary we want to assess if the identified loci are also associated to HbA1C, or if alternative loci are…
To set up a cohort of patients undergoing radiological interventions, which will serve as a platform for randomized evaluation of different pain and anxiety management strategies in order to improve on routine care by searching for a more effective…
The purpose of the registry is to determine disease development of advanced and non-advanced sarcoidosis. In addition, the registry would note the other organ involvemen, treatment and quality of life.
NAM, well known as a dietary supplement, has also been extensively studied in humans in a variety of diseases in both children and adults. However, the safety, tolerability of NAM in children with JIA is yet unknown. Furthermore, studies performed…
The main objective is to investigate the effectiveness of parenting programs addressing family functioning and PTSD within the Dutch veteran population. A secundary objective is to unravel and identify the role of emotion regulation and…
To demonstrate that treatment with avelumab in combination with standard of care (SOC) CRT is superior to SOC CRT alone in prolonging progression-free survival (PFS) in front-line patients with high-risk (as defined in Inclusion Criterion 2),…
The aim of this study is to investigate efficacy of a manuka honey lavage in the treatment of three distinct disorders; persistent clostridium difficile infection (CD), budesonide dependent microscopic colitis (MC), and therapy refractory irritable…
To assess treatment results of light trauma care in the primary care setting, in comparison to light trauma care in the secondary care setting. In addition, we aim to study time consumption and costs.
The main objective is to objectify if the injection of SVF influences the pain of the TMJ during movement. Secondary objectives are pain during rest, maximum mouth opening, and function evaluation.
1. The primary objective of this phase I/II clinical trial is to evaluate the safety and toxicity of ACT plus nivolumab according to CTCAE 4.0 criteria. Toxicity grade 3 or less and SAE related to treatment but that does not result in treatment…
To explore the nature and consequences of feeding and swallowing problems in patients with SMA type II, III, and IV, and to detect predictors of these problems from instrumental, clinical dysphagia assessments and the LINMA(-k) (an adapted…