337 results
Objectives1.3.1 Primary ObjectiveCompare the efficacy of BMS-945429 versus placebo for induction of clinical remission (defined by an absolute Crohn*s Disease Activity Index [CDAI] score < 150) at Week 8 (IP-57).1.3.2 Secondary Objectives•…
Het wetenschappelijk onderzoek naar de meerwaarde van SW 112 op bacteriën/biofilm bij de behandeling van chronische voetulcera staat nog in haar kinderschoenen. Daarom is het doel van het onderhavige onderzoek om meer inzicht te krijgen in de…
Determine efficiency and safety of two different doses of pregabalin as compared to placebo.
Primary Objective: To evaluate tibia rotation after TKA with the Vanguard total knee system with either the XP tibia implant compared to the standard CR tibia implant.Secondary Objective: Comparing operative, clinical and radiological outcome of the…
The objective of the study is to compare the safety and efficacy of masitinib at 4.5 mg/kg/day or masitinib at 4.5 mg/kg/day with a dose escalation to 6 mg/kg/day after three month of treatment versus placebo in the treatment of patients with…
The purpose of this study is to determine whether it is useful to decolonize patients undergoing primary hip or knee replacement surgery from the S. aureus skin bacteria.
Effect of folic acid supplementation in pregnancy on preeclampsia - Folic Acid Clinical
Trial (FACT)
Primary ObjectiveThe overall aim is to evaluate a new preeclampsia (PE) prevention strategy: 4.0mg (1.0mg x 4) of folic acid supplementation vs. placebo from early (80/7 to 166/7 weeks of gestation) pregnancy until delivery.Secondary ObjectivesTo…
Primary Objective:To assess whether the clinical efficacy of RPC1063 is superior to interferon (IFN) *-1a (Avonex®) inreducing the rate of clinical relapses in patients with RMS.Secondary Objectives:- To assess the effect of RPC1063 on the…
Primary objectiveTo assess whether the use of alimemazine improves symptoms of allergic diseases and ADHD, as scored by the parents using standardized questionnaires (Sample Snap IV rating scales)
We aim to study the effects of PEMF on pain in fibromyalgia.
Objective: To determine whether serum concentration guided dosing of infliximab is not inferior to standard dosing based on bodyweight in patients with severe sarcoidosis in terms of FVC change at 26 weeks.
The study will be performed in 2 parts, Parts A and B. The purpose of the study is to investigate to what extent BN201 is tolerated. It will also be investigated how quickly and to what extent BN201 is absorbed and eliminated from the body (this is…
Primary Objective:The primary objective of this study is to evaluate the effect of SRP-4045 and SRP-4053 (combined-active group) compared to placebo onambulation, endurance, and muscle function at Week 96, as measured by the 6-minute walk test (6MWT…
The aim of this study is to investigate the effect of the intranasal cooling (RhinoChill System) on the severity and frequency of withdrawal headache and associated symptoms in the first 7 days during standard care treatment for detoxification of…
Primary endpoint: Evaluation of the safety of the novel anti-TB vaccine RUTI® (25*g FCMtb) in patients with MDR-TB favourably responding to second-line, standard MDRTB treatment through clinical, microbiological, and radiological response criteria.…
The primary aim of this study is to examine the beneficial effects of additional dietary protein supplementation on the endurance-based exercise training-induced changes in VO2max, endurance performance, muscle strength, body composition,…
Primary objective: to establish the effectiveness of laxative therapy in children with functional abdominal pain.Secondary objective: to establish if laxative therapy is effective in all functional abdominal pain syndromes, including functional…
Objective: Identify the effect of tDCS targeting the vmPFC on empathy in persons with traits of psychopathic meanness by measuring effects on an empathy task.
Primary:To assess the efficacy of treatment with IV danirixin twice daily given with oral oseltamivir compared to oral oseltamivir twice daily on time to clinical response (TTCR)Secondary:Time to respiratory response (TTRR), clinical measures of…
To investigate the effects of anodal and cathodal tDCS on gambling compared to sham stimulation. Additionally, changes in EEG activity will be explored.