29 results
To determine and compare plasma levels of rivaroxaban during daytime with a morning and evening intake in patients treated for venous thromboembolism
The purpose of this study is to investigate how safe the new compound OMS906 is and how well it is tolerated when it is administered to healthy volunteers. OMS906 has not been administered to humans before. It has been previously tested in the…
Investigate regulators of (disturbed) iron homeostasis and cellular determinants of iron overload in RHA. to decipher crucial elements of the crosstalk between iron metabolism and erythropoiesis
To establish a point prevalence of asymptomatic proximal lower extremity DVT in patients admitted to the ward with COVID-19.
To evaluate the safety of BIVV001 in previously treated pediatric subjects with hemophilia A.
The main objectives of this study are:1. To identify the role of conformational changes of ADAMTS13 on hyperfibrino(geno)lysis in in vitro coagulation tests (primary)2. To identify the role of plasmin on ADAMTS13 conformation on in vitro coagulation…
The main goal is to establish reference values of new clinical laboratory tests
The aim of this study is to evaluate investigate whether BCRL will improve in patients with BCRL undergoing DIEP-flap BR combined with an inguinal lymph node transplant have statistically significant improvement of their BCRL (primary objective),…
To improve our understanding on the etiology of proximal DVTs, to identify risk factors for stent reinterventions and to optimize treatment after a venous stent. To improve patient education and expectation after a venous stent.
To determine the feasibility and applicability of the MRL protocol by comparing the images in upper extremity in patients with secondary lymphedema and healthy subjects, and to assess differences in the lymphatic system between the lymphedema…
- To evaluate the relative bioavailability between the new eltrombopag capsule formulation (CPS) and the marketed tablet formulation (FCT) at single oral doses of 25 mg and 75 mg, in healthy subjects in the fasted state.- To evaluate the PK…
1. To investigate the efficacy of dual therapy (omitting acetylsalicylic acid) compared to triple therapy in patients with atrial fibrillation and acute coronary syndrome.2. To investigate the safety of dual therapy (omitting acetylsalicylic acid)…
Primary:* To demonstrate the clinical efficacy of rozanolixizumab in maintenance treatment in study participants with primary ITPSecondary:* To assess the safety and tolerability of rozanolixizumabExploratory:* To evaluate the clinical efficacy as…
The aim of this study is to determine whether LNP023 is effective and safe for the treatment of PNH. LNP023 is compared to the Standard of Care (SOC) anti-C5 antibody treatment. The primary objectives are to:• Demonstrate superiority of LNP023…
The overall aim of this project is to delineate the role of neutrophil activity and diversity in the pathogenesis of acute (e.g. vaso-occlusive crisis (VOC) and Acute chest syndrome (ACS)) and chronic complications in sickle cell didease and its…
Study MO41787 will evaluate the efficacy, safety, pharmacokinetics, and pharmacodynamics of emicizumab administered at 3 mg/kg Q2W for a period of 52 weeks in previously untreated patients (PUPs) and minimally treated patients (MTPs) at study…
The primary objective of this study is: to develop a blood vessel-on-chip model that mimics hypercoagulability in patients with COVID-19. The secondary objective is: to evaluate the efficacy of agents that inhibit COVID-19-related hypercoagulability…
The aim of this study is twofold: 1) to measure ROTEM profiles in patients at risk for DIC to determine cut off values of ROTEM corresponding to the currently used International Society for Thrombosis and Haemostasis (ISTH) DIC scores, as well as to…
Compare the effect of three different RBC transfusion strategies* (Standard of care (SoC), SoC+1 and SoC+2**) on heart rate in a population of chronically transfused patients (with on average at least 1 RBC transfusion each 8 weeks as personal…
To study the effect of voxelotor on the hemodynamics of the cerebral vasculature (CBF and CVR)