45 results
* To evaluate the in-vivo effects of standard treatment of ATG and cyclosporine on lymphocytes in patients with SAA.* To evaluate persistence and binding capacity of circulating ATG derived antibodies in patients with SAA after treatment.* To…
1. To study the mechanisms that control endothelial and platelet secretion using blood outgrowth endothelial cells (BOECs) as an ex vivo model of endothelial and platelet secretion, in order to identify new regulators of and further unravel their…
Primary objective- Short- and mid-term repeatability of mDLS and LSCI measures;- Comparison of blood flow obtained by LSCI and blood flow obtained by mDLS;- Comparison of coagulation status obtained by mDLS and coagulation status assessed by…
This study aims to provide a more rational evidence base for appropriate management for metastatic melanoma in the groin LNs, through assessing the effect of the addition of ipsilateral pelvic lymphadenectomy on patient disease-free survival (DFS),…
Main study:We want to assess whether bleeding risk in women with uterine leiomyomas is associated with CK activity and attenuated platelet aggregation.Objective of pilot study:Firstly, to perform a feasibility pilot of CK/AK measurement in menstrual…
1. Determine correlation between residual heparinisation and post-operative blood loss after elective cardiac surgery2. Determine the extent to which TEG delta R can predict post-operative blood loss3. Determine the extent to which ACT measurement…
Performance is the primary objective of this study and is defined as the ability of the in vitro diagnostic micro-assay to measure von Willebrand factor induced platelet aggregation in accordance with the golden standard diagnostic method, risto-…
To study the feasibility of single UCBT with one ex-vivo SR-1 expanded unitTo assess side effects and TRM after single UCBT with one expanded unitTo assess engraftment and engraftment kinetics; to evaluate immune reconstitution, acute and chronic…
(Primary) Determine whether measuring the expression level is a good functional test for confirming the genetic diagnosis in IRIDA by establishing the relation between the TMPRSS6 mRNA expression and the phenotype in IRIDA patients and their family…
The influence of Annexin A2 SNP (rs17845226) on von Willebrand factor secretion by endothelial cells
The aim of this research is to study the effect of Annexin A2 SNP rs17845226 on vWF secretion by endothelial cells of controls carrying different Annexin A2 SNP rs17845226 genotypes (WT, homozygous, heterozygous). By testing several endothelial cell…
To assess whether the inhibitory effect of CK on platelet aggregation can be reversed in vitro.
Primary Objective: To assess whether the current use and dosing in cirrhosis of anticoagulation is as effective in inhibiting ex vivo thrombin generation compared to the treatment of patients with competent liver function
The Activation of Coagulation and Inflammation in Trauma (ACIT) study is designed to identify the clinically significant mechanisms and pathways by which inflammation and coagulation are activated immediately following major trauma, and how these…
The purpose of Part 1A is to investigate how safe RO7112689 is and how well RO7112689 is tolerated. Part 1A will also investigate how quickly and to what extent RO7112689 is absorbed into, distributed in, and eliminated from the body (this is called…
To measure the effect of lowering or stopping biologicals on various coagulation parameters in patients with rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis.
The rationale for this protocol is to use standardized procedures to obtain PBMCs from adult patients with a diagnosis of a CD19 expressingmalignancy for which a CTL019 treatment protocol is currently enrolling or under IRB/EC review, and to…
To evaluate the efficacy of low molecular weight heparin (LMWH) in women with inherited thrombophilia and recurrent miscarriage on live birth.
To assess the effectivity of LVA on arm volume in comparison to standard therapy after 12 months.
The primary objective is to compare the haemostatic effect of VHA-guided transfusion strategy versus optimized CCT guided transfusion strategy in haemorrhaging trauma patients. The secondary objectives of the study are to determine the effects of…
The study will compare the change in cutaneous cellular oxygen availability, measured as mitochondrial PO2 (mitoPO2) between a fluid challenge and a blood transfusion in chronic anemia patients.