38 results
The current study aims to evaluate magnetic resonance imaging (MRI)-based CVR measurements with ACZ in SCD. It*s primary objective is to assess whether there is a correlation between CVR with silent cerebral infarcts (SCI) (i.e. the cerebrovascular…
1. To establish whether serial exhaled breath analysis using eNose can detect invasive pulmonary aspergillosis in patients with prolonged chemotherapy induced neutropenia (neutrophil counts <0.5 x 10^9 for more than 7 days).2. To establish…
Objective of the study is to evaluate whether parameters can be identified that predict which graft ultimately prevails following cord blood transplantation after a reduced intensity conditioning regimen in adult patients .In addition engraftment,…
This study aims to collect biochemical evidence for the pro-hemostatic capacity of DDAVP in patients with cirrhosis, in order to proceed towards a more rational clinical use of this drug.
Evaluate whether FVIII/VWF concentrates successfully induce immune tolerance in patients who have already experienced and failed immune tolerance induction with VWF-free FVIII concentrates.
To get more insight into lymphocyte kinetics during immune reconstitution after hematopoietic stem cell transplantation
Bloodloss study after Aortic valve replacement
Impact of Mecc perfusion vs conventional ECCperfusion
Peri-operative Bloodloss after Aortic valve replacement
The objective of this study is to collect blood samples of women who participated in the ALIFE trial, to test for several DNA-variations as well as anti β2 glycoprotein antibodies, but also to perform overall coagulation assays, such as clot lysis…
The Activation of Coagulation and Inflammation in Trauma (ACIT) study is designed to identify the clinically significant mechanisms and pathways by which inflammation and coagulation are activated immediately following major trauma, and how these…
Core StudyPrimary objective• To compare the efficacy of E5501 (in addition to standard of care) to eltrombopag (in addition to standard of care) for the treatment of adult subjects with chronic immune thrombocytopenia (idiopathic thrombocytopenic…
The objective of this study is to investigate whether thrombin generation is effected by different shear rates and different tissue factor concentrations in plasma, platelet rich plasma and whole blood. Thrombin generation in plasma with/without…
Part 1 (open-label, 8 week): safety and tolerability of eltrombopag, optimal dose escalation scheme for use in Part 2, PK.Part 2: Primary: the reduction in the number of clinically relevant thrombocytopenic events (*Grade 3 hemorrhagic adverse…
To investigate if ultra low-dose chest CT may be a better diagnostic tool than chest X-ray on day 1 of febrile neutropenia. Imaging results will be compared with a consensus diagnosis on the cause of febrile neutropenia made by an expert panel.…
To assess the prevalence, severity and impact of arthropathy in patients with moderate or severe VWD and a history of documented DDAVP or clotting factor concentrate treatment for joint bleeds. To compare arthropathy in these patients to age, FVIII…
To elucidate the pathogenetic mechanism of endothelial cell activation in DENV infected patients with sickle cell disorder.
To evaluate the efficacy of low molecular weight heparin (LMWH) in women with inherited thrombophilia and recurrent miscarriage on live birth.
-Assess the incidence of major bleeding and clinically relevant non-major bleeding -Assess the incidence of recurrent venous thromboembolism -Characterize the pharmacokinetic/ pharmacodynamic profile of a 30-day treatment with oral rivaroxaban
In the present ex vivo study we aim to determine whether thromboelastometry parameters, in particular the lysis onset time (LOT), are appropriate to determine and quantify the degree of hyperfibrinolysis. Furthermore, we will study the association…
The main object is to evaluate the validity of a diagnostic screening package for bleeding tendency consisting of point-of-care devices when compared with the gold standard for bleeding tendency diagnosis.Other objects which will be investigated are…
To investigate in a randomized controlled trial, whether giving Cofact pre-operatively can reduce the bloodloss and transfusion requirements during orthotopic liver transplantation. Also we investigate the safety of Cofact in this patient population…