33 results
1. Determining whether or not the vitamin K tablets have the same biological availability in humans as the vitamin K solution has.2. Determining whether or not the vitamin K tablets are as effective as the vitamin K solution is.
We will study the effects of the proteins of the contact activation system in thrombus formation, embolization and degradation in several coagulation assays.
To assess the costs and effects of tailoring the duration of elastic compression stocking (ECS) therapy after deep vein thrombosis (DVT) to individual patients needs.
The objectives of the complete NIMBL study are as follows:Objective 1. Gain insight into the natural history of AGS and RVCL* Create a registry of paediatric and adult AGS and RVCL patients, and develop a network of clinicians caring for these…
Primary:- to assess the multiple-dose pharmacokinetics of apixaban and rivaroxaban - to compare plasma concentration peak to trough ratio (Cmax/Cmin) of rivaroxaban to apixaban Secondary:- to assess the multiple dose pharmacodynamics (anti-Factor Xa…
In this study, we will assess whether healthy men with high-normal serum CK display attenuated platelet aggregation, compared to those with low-normal serum CK.
The aim of the study is to understand the effects of CPB on coagulation and fibrinolysis to improve treatment of excessive blood loss (>2L/24 hours or >200 mL/hour) after cardiac surgery.The objective of this study is to differentiate…
To evaluate the efficacy of incentive spirometry on the incidence of ACS in adult sickle cell patients admitted with a vaso-occlusive painful crisis.
Primary: to evaluate the pharmacokinetics of a single 100 mg dose of CAL-101 administered as a capsule (unmicronized formulation), a capsule (micronized formulation) or a tablet in normal healthy male subjectsSecondary: to evaluate the safety of a…
The aim of this study is to evaluate fibrinogen concentrations, coagulation and fibrinolysis during and after CABG, to characterize the ex vivo effects of rhFGN variant Aα610 (wild type) and Aα847 when added to blood samples collected after CABG,…
-To assess the feasibility of relatively frequent measurements of whole blood platelet aggregometry using collagen as inducer;-To assess the effects of ASA treatment on collagen-induced platelet aggregation (primary endpoint);-To investigate the…
A study to investigate the safety, pharmacokinetics and pharmacodynamics of a new recombinant human factor VIIa in healthy males, compared to Novoseven.
Serum hepcidin levels are elevated in hemodialysis patients and may contribute to functional iron impairment and thus to ESA-resistance. Kinetics of hepcidin in hemodialysis patients has not been studied in detail. This study is designed to provide…
to determine the immediate effects of alcohol consumption in healthy volunteers on haemostasis and to evaluate the differences of artificially alcoholised blood and *naturally*, via oral uptake alcoholised blood on haemostasis as measured by…
Primary: To determine whether IL-1 inhibition by Canakinumab is efficacious in treatment of Schnitzler syndrome.Secondary:1. To assess the effect of canakinumab on Schnitzler syndrome (clinical signs/symptoms and inflammatory biomarkers C-reactive…
2.1 Primary Objective• Evaluation of the levels of thrombophilic factors in the blood of HIV-infected patients before starting with cART and the changes of these levels when on cART for the time of one year. 2.2 Secondary Objective• Evaluation of…
We aim to evaluate the use of MRDTI in the diagnosis of acute proximal DVT, comparing the findings with CUS. To evaluate the outcome of patients with positive and negative MRDTI and CUS, clinical outcome after 3 months of follow-up will be measured…
Assess the efficacy and safety of eculizumab in pediatric patients with aHUS to control TMA as characterized by thrombocytopenia, hemolysis and renal impairment.
Assess the efficacy of eculizumab in adult patients with aHUS to control TMA as characterized by thrombocytopenia, hemolysis and renal impairment.
To study whether microcirculatory perfusion is improved by ECMO. Perfusion will be studied before & after ECMO start, during ECMO weaning and before & after ECMO stop. To study the precictive value of perfusion and its correlation…