71 results
To test the hypothesis that observing the data and waveforms displayed on an RFM during the provision of positive pressure ventilation to preterm infants at birth will increase the proportion of tidal volumes within a predefined *safe range* of 4 -…
Primary Objectives: The primary objectives of this study are to evaluate the efficacy and safety of IV sildenafil when added to iNO for the treatment of neonates with PPHN or hypoxic respiratory failure and at risk for PPHN. Secondary Objectives: *…
To assess the one-year (cost)effectiveness of self-management support via an internet-based service in addition to usual care as compared to usual care alone in a pragmatic trial in patients with severe asthma who are referred for a pulmonary…
First Objective: Is the percentage of subjects that dynamic hyperinflate during activities of daily living larger in patients with mild COPD than in healthy controls?Second Objective(s): Will dynamic hyperinflation induced by activities of daily…
The primary aim of this observational study is to determine the occurrence of exercise-induced left ventricular diastolic dysfunction (LV-DD) in symptomatic COPD patients with a normal echocardiography at rest. And, secondly, to study the…
Primary Objective: to determine the feasibility of supported MV with low tidal volumes after partial neuromuscular blockade in patients with high respiratory drive. Secondary Objective: to determine the effect of partial neuromuscular blockade on…
Primary: Assess the effect of i.v. infusions of BYM338 on muscle volume of the thigh (assessed by MRI) at 4, 8, 16 and 24 weeks, compared to placebo, in COPD patients with pulmonary cachexia.Secondary: Effect on 6-minute walk test, safety and…
The main objective of this study is to measure the effects of the monitoring and feedback tool embedded in a Self-management Support Program on physical activity. The secondary objective is to measure the effect on self-efficacy, quality of life and…
The primary aim of this observational study is to determine the occurrence of (exercise-induced) pulmonary hypertension (sPAP > 40 mmHg) in IIP patients with an elevated V*E/V*CO2 at AT (> 34) assessed during CPET. And, secondly to…
Objective: To perform a study comparing the efficacy of extra-fine particle HFA-QVAR 200 µg b.i.d. to an equipotent dose of course particle HFA-beclomethasone (HFA-Clenil) 400 µg b.i.d. and with coarse particle HFA-fluticasone (GSK) 250 µg in ex-…
Efficacy and safety.
Primary objective- To define the optimal pressure support level for homogeneous lung ventilation during PSV, based on EIT measurements, in patients with and without lung disorders.Secondary objectives- Improved oxygenation compared to baseline-…
Primary: to assess the longterm safety and tolerability of ambrisentan 5mg in subjects with inoperable CTEPH. Secondary: to collect supportive efficacy data.
This study is designed to evaluate the safety and performance of SinuBand, a bioresorbablefluticasone propionate-eluting sinus dressing in the postoperative management of FESS in patientswith chronic rhinosinusitis. The study will collect both…
To provide continued treatment with trametinib.
The Purpose of the study is to investigate the clinical feasibility of the TW15 and TW22.
The objective of the proposed study (1237.25) is to evaluate maximal treatment effect in FEV1 and SGRQ after 12-weeks treatment with two different doses of tiotropium + olodaterol FDC (5*g/ 5*g and 5*g/ 2.5*g) by comparison with placebo in patients…
Efficacy and safety.
The primary objective of this study is to provide the LVRC procedure and safety and effectiveness follow up to qualifying subjects who were enrolled as Control Subjects in and completed the 12 month visit of the Lung Volume Reduction Coil Treatment…
We propose to develop a multicenter registry of sarcoidosis associated pulmonary hypertension (SAPH). With this registry, we will characterize the demographics, clinical course, hemodynamics, pulmonary physiology, and disease management of…