335 results
Primary: Assess the effect of i.v. infusions of BYM338 on muscle volume of the thigh (assessed by MRI) at 4, 8, 16 and 24 weeks, compared to placebo, in COPD patients with pulmonary cachexia.Secondary: Effect on 6-minute walk test, safety and…
In deze studie zal de nauwkeurigheid van peroperatieve meting van de cuppositie door een nieuw ontworpen, onlangs gepatenteerd, meetinstrument worden onderzocht. In de toekomst kan, indien het meetinstrument betrouwbaar blijkt, peroperatief de…
To identify risk factors for injuries in novice runners, and to identify risk factors for specific injuries.Secondary Objective(s): 1. To determine the incidence of running related injuries in novice runners2. To describe the health benefits of the…
In this study we aim to examine the effects of a low dosage of prophylactic haloperidol in patients with an expected ICU length of stay of >1 day. We use two different dosages of haloperidol in this study to compare with placebo. A dosage of…
Primary-To compare CYP2D6 clinical phenotype by a 13C-DM-BT in LBC patients with MBC patients, and are currently using tamoxifen -To correlate CYP2D6 clinical phenotype by 13C-DM-BT to serum endoxifen levels in LBC and MBC patientsSecondary---To…
The purpose of this study is to determine the thermal parameters by MRI scans at different time points during head-neck radiotherapy combined with hyperthermia treatment series.
We will examine effectiveness of the internet-based self-help intervention compared to a waiting list control condition on (1) reduction of depressive and anxiety symptoms post intervention and 6 weeks post-partum and (2) improvement in perinatal…
Primary objectives: 1. Does vitamin D supplementation improve depressive symptoms in older persons? 2. Does vitamin D supplementation improve physical performance and functional limitations in older persons?Secondary objectives: 3. Does vitamin D…
Predicting fluid responsiveness during PLR and fluid challenge (FC) by changes in (Pms).
The study is intended to provide insight into the clinical feasibility of the Exilis* system as a therapy for obesity, including:* Providing initial human safety data on the Exilis* system, * Gaining an understanding of how to individually titrate…
The primary aim of this study is to validate the paradigms designed to investigate the effects of social stress and reward on in healthy individuals. This will allow us to evaluate and optimize the experimental paradigms in terms of their design,…
In this study, we will assess the tolerability of GPA in healthy male volunteersFurthermore, we will assess the effect of GPA and creatine on hemodynamic, biochemical parameters and ADP-dependent plateletaggregation of healthy male volunteers.
Determining the effect of long-term weight loss after bariatric surgery on:- striatal dopamine D2/3 receptor availability - behavioral parameters- plasma hormones, metabolites and peptides involved in appetite regulation, and glucose metabolism
to develop a *two hit* in vivo autologous RBCs transfusion model in healthy male volunteers.
We study training effects in patients that receive training in the early CVA-phase (CVA < 6 weeks).Goals:1. Determination of the training effects in the early phase of stroke. 2. Determination of quality of life in trained CVA patients with…
Primary Objective: To determine if spinal and cortical balance control mechanisms mediate the age-associated decline inbalance skills.Secondary Objective: To determine the reliability of TMS and H-reflex measures in the soleus muscle in different…
The objective of the current study is to determine whether the presence of donor-specific B cell memory determines whether a patient will develop graft rejection or inferior graft function, especially in kidney transplant recipients who have donor-…
The aim of this study is to see if we can enhance the effectiveness of the nurse*s comforting capabilities through the addition of maternal scent communication during heellance.
Objective of the project is to the American EDDI translate and adapt to the Dutch situation. Then, in a pilot study there will be examined whether the intervention is applicable to people with dementia and their caregiver, and if so, under what…
To examine the behavioural and neural effects of a single session of post-learning exercise on long-term memory retention in humans.