92 results
To investigate the potential of a novel dietary substrate preparation to enhance muscle mitochondrial function in GSD IIIa via acute nutritional ketosis. Secondary objectives are to further investigate in vivo exercise tolerance and intramuscular…
To compare acylated and unacylated ghrelin concentrations in pregnant women with GD and without GD.
To investigate if difference in fiber type and/or oxygen supply are the underlying cause for the difference in PCr recovery along the length of the tibialis anterior muscle.
To characterize phenotypical parameters, cytokine production and epigenetic characteristics of monocytes in patients with diabetes mellitus type 2, stratified according to antidiabetic treatment regime. Ex vivo exploration of the conditions which…
To study the pharmacokinetics of non-reactive labelled histidine (L-HISTIDINE:HCL:H2O (D5, 98%; 15N3,98%) and the effect on intestinal imidazole propionate (IP)production in small intestine vs colon in healthy controls, metabolic syndrome and DM2…
To investigate the impact of (a disrupted) circadian rhythm on food preferences and chemosensory perception.
The primary objective is to identify additional genetic loci associated with skin fluorescence in patients with type 1 diabetes Mellitus. Secondary we want to assess if the identified loci are also associated to HbA1C, or if alternative loci are…
Primary:To investigate change in 24-hr sodium excretion during dapagliflozintreatment between Baseline (average of Days *3 to *1) and averageof Days 2 to 4 within each study group in patients withtype 2 diabetes mellitus (T2DM) with preserved or…
Primary :The primary objective is to evaluate the effect of inclisiran treatment on:* LDL-C levels at Day 510.* Time adjusted percent change in LDL-C levels from baseline after Day 90 up to Day 540 levelsSecondary:The secondary objectives are to…
The overall aim is to study the effects of a lifestyle intervention for young women who are pregnant <= 12 weeks of gestational age and have a high risk on perinatal morbidity because of prepregnancy overweight or obesity and, if applicable,…
Investigate the stability and reproducibility of PAI when applied to the diabetic foot. Further, we aim to compare results from PAI with the currently used non-invasive blood pressure measurements.
1. To identify a biomarker of hepatic DNL in different disease models of NAFLD. 2. To assess the cardiovascular risk profile in the different disease models of NAFLD.
The primary objectives are to investigate which determinants (primarily carnitine status) determine the effect of carnitine supplementation on metabolic flexibility and insulin sensitivity in patients with type 2 diabetes. Furthermore, a secondary…
In this randomised, double-blind, placebo-controlled cross-over single centre study we propose to study the effect of duodenal infusion of single E. Hallii treatment of 10 ml 10E9/ml in 10% glycerol or 10ml 10 % glycerol (administered via duodenal…
The primary objective of this study is to evaluate the efficacy of BIIB074 in treating pain experienced by subjects with confirmed SFN that is idiopathic or associated with diabetes mellitus.Sub study objective:Corneal Confocal Microscopy (CCM) as a…
To examine the effects of mono- and combination therapy with linagliptin and empagliflozine on renal hemodynamics
The main purpose of this trial is to find out if an investigational drug called setmelanotide (RM-493), which mimics MSH, can help control body weight. The efficacy of setmelanotide will be compared to the efficacy of a placebo during 4 to 8 weeks.
The main objective is to define the self-test performance by means of the Total Error for the Medimate Minilab 2017 for the set of parameters.
The primary objective of the study is to evaluate the reduction of low density lipoprotein cholesterol (LDL-C) by evinacumab in comparison to placebo after 16 weeks in patients with primary hypercholesterolemia (heterozygous familial…
The main study objective is to measure residual beta cell mass, indicated by the pancreatic uptake of Ga-68-exendin using quantitative PET, in type 1 diabetes patients with stable near-normal and unstable glucose control, to improve understanding of…