309 results
Primary ObjectiveTo assess the effect of ABT-981 on OA knee pain using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) at Week 16 and synovitis/effusion volume of the index knee using quantitative measures and semi-…
Primary: To demonstrate that the efficacy of secukinumab 150 mg s.c. or 300 mg s.c., at Week 24 is superior to placebobased on proportion of subjects achieving ACR20 response in subjects with active PsA.Secondary:- mTTS structural damage week 24-…
To assess the effect of CAC with effective temperature on pain sensation and consumption of narcotics in patients operated for TKA after 7days postoperative compared to CAC without effective temperature.
To define a dose-response relationship after intrinsically labeled milk protein ingestion on myofibrillar and mitochondrial muscle protein synthesis after a single bout of endurance exercise.
The principal aims of the study are to assess: 1. The effectiveness of a 5 day treatment course in arresting/ resolving episodic knee arthralgia/ flaring knee pain.2. The relative effectiveness of a low dose (1200 mg/day) of lipid formulated…
The primary objective is to compare change in weekly average daily pain score (ADPS) from baseline to Week 13 in subjects receiving either dose of DS-5565 versus placebo. Weekly ADPS is based on daily pain scores reported by the subject that best…
Primary objective: The primary purpose of the research is to determine the difference in pain experience during rest, measured by means of an 11-point Numerical Rating Scale (NRS), between peroperatieve Local infiltration with Analgesics (LIA) vs.…
Primary Objective: To evaluate tibia rotation after TKA with the Vanguard total knee system with either the XP tibia implant compared to the standard CR tibia implant.Secondary Objective: Comparing operative, clinical and radiological outcome of the…
The purpose of this study is to determine whether it is useful to decolonize patients undergoing primary hip or knee replacement surgery from the S. aureus skin bacteria.
The main objective of this prospective randomized study is to examine the effect of low-dose radiotherapy on pain sensation in patients with early OA of the hip. Our hypothesis is that radiotherapy can achieve a pain-reducing effect of at least 20%…
1. To assess the correlation between the use of bioabsorbable anchors and the early postoperative rate of shoulder stiffness in comparison to the use of non-absorbable titanium and synthetic (PEEK) anchors in arthroscopic rotator cuff repair.2. To…
Primary: to demonstrate that at least one dose regimen of BYM338 in sporadic inclusion body myositis patients will increase the distance traveled as measured by change from baseline at Week 52 of the 6 minute walking distance test relative to…
The objective of the current study is to compare three different strategies of pain management in patients presenting to an emergency department and to a general practice with acute musculoskeletal syndromes (defined as musculoskeletal complaints…
PrimaryThe primary objective is to evaluate the effect of ABT-981 on pain using the Australian/Canadian Osteoarthritis Hand Index (AUSCAN NR3.1) pain subdomain score, in subjects with erosive hand OA at Week 16.Secundary* Evaluate the safety and…
Overall Objective: To define the properties of whey, casein, milk protein, as well as soy protein with and without additional leucine to augment post-exercise muscle protein synthesis when co-ingested with a carbohydrate containing recovery drink.…
Objective: non-inferiority in fixation of the SL-PLUS MIA compared to the traditional SL-Plus stem and superiority of the SL-PLUS MIA in terms of bone and muscle preservation and thereby increased patient satisfaction and outcome as measured by PROM…
(1) To phenotype chronic low back pain patients in terms of endogenous modulation of pain, central sensitization/facilitation, and the presence of a neuropathic pain component;(2) To assess the effect of a three-month treatment with tapentadol on…
To provide evidence for the efficacy of Branched Chain Keto Acids (BCKA) and Branched Chain Amino Acids (BCAA) when compared with milk proteins to stimulate postprandial muscle protein synthesis in vivo in healthy older humans.
Primary Objective:The primary objective of this study is to evaluate the effect of SRP-4045 and SRP-4053 (combined-active group) compared to placebo onambulation, endurance, and muscle function at Week 96, as measured by the 6-minute walk test (6MWT…
This study is not intended to improve your health, but is necessary for the further development of RO7034067 .The study will be performed in 3 parts, Parts 1, 2 and 3. This document only refers to Part 1/2/3 of the study . Part 1:A single dose will…