17 results
Primary Objectives:The primary objective for this study is to evaluate the proportion of subjects who achieve SVR12 (HCV RNA < LLOQ (target not detected) at post-treatment follow-up Week 12 in subjects with GT-1b, -4 and GT-2, -3.Secondary…
Prevention of NAS will result in less retransplantations due to NAS. This in turn will result in a shorter waiting list with less morbidity and more important less mortality while waiting for a donor liver. Patients will also be less often…
investigate the relationship between il28b and apolipoproteine E genotype and response to interferon
The primary objectives of this study are:•To explore the antiviral efficacy of combination therapy with SOF/LDV FDC + RBV for12 or 24 weeks in subjects with advanced liver disease (either pre-liver transplant or notcurrently wait-listed) and post-…
To evaluate in detail the functionality of immune cells in blood in chronic HCV patients before, during and after treatment with ASV and DCV, in an IFN-free regimen.
The primary objective of this study is:• To evaluate whether simtuzumab (formally referred to as GS-6624) is effective at preventing the progression of liver fibrosis in subjects with PSC.The secondary objectives of this study include the following…
Primary objective:To show that concomitant use of telaprevir (1125 mg BID) does not lead to a relevant decrease (> 20%) in the paroxetine parameter AUC0-24h compared to paroxetine alone.Secondary objectives:To determine the ratio of the…
The objective of this study is to evaluate efficacy and safety of regorafenib in patients with HCC who have progressed after sorafenib.
This is a Dutch multi-centre study that aims to complete patient accrual through national collaboration. Patients with resectable PHC will be randomized to undergo either EBD or PTBD. The objective of the study is to identify a difference in the…
The purpose of this study is to provide safety and efficacy data for the X-Suit NIR® Covered Biliary Metallic Stent. The study is designed to support the regulatory requirement of a 510(k) marketing application in the United States.The objective of…
The aim of this study is to retrieve extra measurements by Nexfin and laboratory testing in the per- and postoperative period. Can the use of Nexfin contribute in the generation of meaningful data to get an idea of the hemodynamic state of the…
The aim of this study is to investigate the T cell immune system in relation to viral kinetics in acute HBV infection in order to obtain more insight into mechanisms of failure of viral control and development of chronic HBV infection, and to…
Primary: To assess the effects of cholestasis on metabolism of five drugs, who are metabolized by 5 different CYP P450 isoforms.Secondary: To correlate the effect of cholestasis on drug metabolism with the effect of cholestasis on bile acid…
Our principal aim is to assess the effects of phlebotomy on aortic augmentation (AIx) and central BP in supine position and after standing; second, to assess the effects of counter maneuvers (leg crossing and thigh compression) on aortic…
In this study we would like to investigate whether repetitive allogeneic (lean donor) fecal transplantations can reduce liversteatosis and if so which (small) intestinal bacteria cause this inflammation in the liver resulting in subsequent chronic…
-The primary objective of this study is to investigate the pharmacokinetics (PK) of olaparib after a single oral dose of 300 mg to patients with advanced solid tumours and mild or moderate hepatic impairment compared to those with normal hepatic…
Current practice variation in selection of patients with gallbladder stones and abdominal complaints for cholecystectomy is not efficient. Here we evaluate stepwise selection for surgery to improve patient outcome and to reduce the number of…