122 results
Primary objectives:1. To determine the effect of the use of a tailored intervention protocol (regarding reduced antimicrobial use, improving hygiene and changing the animal contact structure) on pig and veal farms on the degree of antimicrobial…
Primary Objective: *To evaluate the immune responses 1 month after 3 doses of 13vPnC as measured by fold rises of serotype-specific immunoglobulin G (IgG) geometric mean concentrations (GMCs) in subjects *2 years of age. Secondary Objectives: *To…
• To assess the feasibility, tolerability and safety of administration of donor or patient derived CMV pp65-specific T cells in patients with CMV reactivation or CMV disease after alloSCT.• To determine the presence of CMV specific T cells at…
• to describe the epidemiological trends of dengue infections imported to Europe by returning travelers• to describe the full clinical spectrum of dengue disease imported to Europe by returning travelers• to report the phylogeny, selection pressure…
1: Elucidation of the factors that cause the complement deficiency in pediatric oncology patients. First, we will characterize the inhibitor of MASP-2 activity in patients during chemotherapy. 2: Identification of the complement component(s) causing…
To evaluate neurologic- and cognitive disorders, neuroimaging and ophthalmological alterations in perinatally HIV-infected children in comparison to matched (with respect to age, sex, race, home environment and socio-economic status) healthy…
I. Evaluation of the nature and maintenance of specific cellular immune mechanisms after infection with Bordetella pertussis in different age groups, to identify critical parameters for pertussis re-emergenceII. To relate individual patient*s…
Main objective: To quantify mumps transmission parameters in exposed individuals, comparing symptomatic and asymptomatic cases, to understand and model ongoing transmission; Secondary: to assess cellular immuunresponses in mumps exposed infected and…
To estimate the risk of Q fever infection in children and adolescents in various exposure groups, estimate the true regional incidence of Q fever infections in children and adolescents, identify associated risk factors, and assess the impact of Q…
1. To determine clinical symptoms of Dientamoeba fragilis infection. 2. To evaluate the efficacy and safety of clioquinol versus metronidazol in the treatment of Dientamoeba fragilis in children.3. To evaluate the duration of positive PCR…
The primary objective of this study is to evaluate the PK of POS administered orally at three dosage levels to immunocompromised children with expected neutropenia (selected oncology patients, aplastic anemia patients and patients which undergo a…
To determine the efficacy of antibiotic prophylaxis after a tick bite in the Dutch setting, in relation to tick infection, tick engorgement and attachment time.
Primary objective: To investigate whether pharmacokinetics of the recommended dose of inhaled tobramycin, defined as serum tobramycin Area Under the Curve (AUC0-24hr), with the I-neb (75 mg) is equivalent to the PariLCPlus (300 mg) nebuliser in…
The assessment of the duration of the cellular immunity to Bordetella pertussis after an extra ACV booster and the relationship between the memory B- cells and antibody responses. The methods used in the study are:B- and T- cell memory responses and…
The main purpose of this study is to determine the appropriate age (10, 12 or 15 years) for a second MenC conjugate (MenCC) vaccine immunization in Dutch children that received a primary MenCC vaccination at a young age. A conclusion will be based…
To protect children with hiv and children using immune-suppressive medication against hepatitis A and B, and to determine the immunogenicity of the combined hepatitis A and B vaccine in these children.
To determine the relative bioavailability of ciprofloxacin oral suspension versus oral tablets in pediatric cancer patients, and to determine the absolute bioavailability of tablets and suspension utilizing the 100% bioavailability of intravenous…
Investigation of the prevalence of sinonasal disease on CT-sinus in children with Cystic Fibrosis at different ages. This study will focus especially on the onset of sinonasal pathology in Cystic Fibrosis in relation to the development of the…
The aim of this study is to investigate the immune response to a tetravalent MenACWY-TT vaccine in 10-, 12- and 15-year old children primed with the monovalent MenC-TT conjugate vaccine at a young age and to1. determine whether the MenC-specific…
Objective: Using an animal model for measles, we have recently developed a hypothesis to explain the mechanism of measles immune suppression (De Vries et al., PLoS Pathogens 8:e1002885, 2012). We hypothesize that MV causes massive infection and…