132 results
Our study will measure several different symptoms/aspects of cellulitis, such as redness, swelling, warmth, pain, fluctuation, ulceration and drainage. Each of these aspects will be scored on a scale of 0-3, adding up to a maximum total score of 21…
To understand the transmission and acquisition of anorectal CT infections in women (i.e. to and from their male sexual partners and to and from the anal and genital region of the same woman), in women who receive routine care, in order to inform…
To investigate whether a 200 mg bid fixed dosage regimen of ciprofloxacin achieves concentrations associated with maximal efficacy and minimal spread of resistance in ICU patients undergoing CVVHD.
To evaluate whether neuromuscular ultrasound discriminates between patients with and without ICU-AW.To detect differences between patients that do and do not have ICU-AW in order to determine relevant cut-offs which can be used in future diagnostic…
The main objective is to assess target attainment of cefotaxime levels in the critically ill treated with either continuously or intermittently dosed cefotaxime. Secondary objectives are: to develop a predictive mathematical pharmacokinetic (PK)…
Development and prospective validation of a pharmacokinetic model of flucloxacillin for dosing in patients with impaired renal function.
Primary ObjectiveTo determine the prevalence of respiratory viral colonization/infection in pre-term born neonates during hospitalisation.Secondary Objectives1. To study the relation of viral respiratory colonization with respiratory support2. To…
the first objective of this study is to quantify the impact of chronic Q-fever or QFS on work status and psychosocial functioning. Secondly, we will identify factors that are associated with these limitations, to determine which subgroups of…
Primary objective is to assess in vivo neuroinflammation quantitatively in patients with sepsis. Secondary objective is to study whether differences in in vivo neuroinflammation are related to long term cognitive outcomes.
Investigate the incidence and severity of early coagulopathy in severe sepsis and septic shock patients and investigate the correlation between these coagulation disturbances and the incidence and severity of microvascular changes.
The primary objective of this study is to monitor changes in oral health during a 3.5-month naval mission and once one month thereafter.
The aim of this study is to analyze the long-term effect of full-mouth tooth extraction on the oral microflora, using the 16S next-generation sequencing technique.
a pilot study will be performed to gain understanding in cognitive functioning in patients with chronic Q-fever or QFS compared to matched controls.
To gain insight in the pharmacokinetics of sinecathechins ointment 10% (Veregen) applied on healthy skin, using Raman micro-spectroscopy and chromatography of tape strips.
Primary objective:To determine the incidence of Clostridium difficile infection (CDI) in hospitalized patients aged * 50 years old and receiving oral or intravenous fluoroquinolones, cephalosporins, penicillins + beta-lactamase inhibitors,…
Objective of the study is to quantify the microbiological etiology in immunocompromised patients, at least 18 years of age, with CAP needing hospitalization. And to determine the severity, antibiotic use and outcome of CAP in immunocompromised…
To identify and clone antibodies that can neutralize the bacterial pathogens Escherichia coli and Pseudomonas aeruginosa.
The objective of the study is to determine the prevalence of antibiotic resistant E. coli, S. aureus and K. pneumoniae strains in residents of Rotterdam visiting general practitioners in neighborhoods with low socioeconomic status (…
1) To estimate the proportion of children aged * 6 months with sepsis-like syndrome (SLS) which is attributable to Enterovirus (EV) or Human Parechovirus (HPeV) infection.2) To estimate the proportions of cases of ARI in children aged 0 to 5 years…
To evaluate the role of white blood cell (WBC) scintigraphy in monitoring the response of infection treatment of a prosthetic joint infection.