267 results
To determine the efficacy and safety of laser therapy in diabetes patients with risk factors for developing diabetic foot complications.
The overall aim of the proposed project is to identify mild PID in elderly patients that distinguish patients with RRTI from individuals with a healthy ageing innate and adaptive immune system. In innate immunity, normal immunosenescence is…
Primary Objective: Create a complete transcriptome of blood cells from dichotomous HIV-2 infection.Secondary Objective(s): Define host factors and pathways that are implicated in the pathogenesis of HIV infection. Determine of the mechanisms that…
Investigate whether switch from a non-nucleoside reverse transcriptase inhibitor (NNRTI)- or protease inhibitor (PI)-based regimen to a raltegravir-based regimen results in reduced platelet reactivity, reduced platelet-leukocyte aggregate formation…
Primary objective:To compare the change in small airways obstruction (FEF75%) in patients with CF when inhaling one ampule of inhaled tobramycin with the Akita® compared to standard of treatment (twice daily nebulization of one ampule using standard…
The main objective of this study is to investigate the effectiveness of the self-help program compared to a waiting-list control group in reducing depressive symptoms. Secondary objectives include the investigation of moderators and mediators of…
Study of the phenotype and function of NK cells obtained from peripheral blood and liver of patients who are successfully being treated for at least 3-4 years for their chronic HBV infection with tenofovir in a flow-up study (METC nr. 2008-271).
(i) to determine specificity of Q-detect* for registration purposes. (ii) to design a decision tree for follow-up of patients with a positive Q-detect* and
Primary ObjectiveTo determine the prevalence of respiratory viral colonization/infection in pre-term born neonates during hospitalisation.Secondary Objectives1. To study the relation of viral respiratory colonization with respiratory support2. To…
This study will try to objectify if C. Burnetii is able to induce epigenetic changes in monocytes and macrophages, ultimately resulting in a changed cytokine profile. Subsequently, this study will try to link these epigenetic changes to mRNA…
1. Characterize the interplay between host factors and bacterial factors and the specific activation of inflammatory pathways.2. Evaluate the expression of identified risk genes after activation of inflammatory pathways in host immune mediating…
Primary objective:To evaluate the efficacy of a RPV based HAART in patients that switch from NVP with FTC, TDF or lamivudine (3TC), TDF or 3TC, zidovudine (ZDV) to RPV/FTC/TDF.Secondary objectives:To measure the impact (strength and duration) of NVP…
PrimaryTo determine whether the palatability of a newly developed formulation of valacyclovir is non-inferior to administration of crushed and suspended tablets in children, is the primary objective of the second phase of the trial.The primary…
The main objective is to investigate the additional value of CRP-POCT (C-reactive protein point-of-care-test) testing in patients suspected of airway infections in long-term care facilities.
To identify and clone antibodies that can neutralize the bacterial pathogens Escherichia coli and Pseudomonas aeruginosa.
Primary objective:To establish four healthy donors for future CHHI studies
Step 1 Primary objective: To describe the population pharmacokinetics of flucloxacillin for non-critically ill patients and determine the influence of covariates (demographics and renal function) on the kinetics of flucloxacillin. Step 2Primary…
To evaluate the effect of chemotherapy on the serological and cellular immune response to influenza virus vaccination in patients with breast or colorectal cancer in order to establisch the optimal timing of vaccination during treatment with…
The main objective of this part of the study (Work Package 1, WP1) which is part of a n European Union funded FP7 project entitled EUCLIDS is to develop, maintain and regulate the clinical network required to collect clinical data and patient…