60 results
To determine the efficacy of a filter-based depletion of RBC-pathogen complexes by a single apheresis tretatment in patients with sepsis.
Local antimycotic treatment of fungal toenail infection is more effective than placebo
The main objective is to determine in what optimal dose PTX should be used in preterm infants suffering from sepsis. Previous clinical studies have already indicated the safety of the drug in preterm infants.
Primary Objective: To prospectively compare outcomes of subjects with diabetic foot osteomyelitis treated with antibiotics targeted at culture results from bone biopsy (intervention group) versus therapy targeted at ulcer bed biopsy culture results…
Primary objectives:Evaluation of efficacy of multispecific T-cell transfer in patients with chemo-refractory viral infections after allogeneic stem cell transplantationSecondary objectives:- Incidence and severity of newly occurring GvHD- Incidence…
The main objective of this trial will be to get a better insight in the influence of age and age-related changes by internal and external factors on vaccine-induced immune responses and gain knowledge on the trajectory of immune decline in older…
To assess the efficacy of a single, oral, 3 grams (g) dose of zoliflodacin compared to a combination of a singleintramuscular (IM) 500 milligram (mg) dose of ceftriaxone and a single 1 g oral dose of azithromycin for the treatment ofuncomplicated…
Determine the B-cell antibody response in patients with Staphylococcus aureus, Klebsiella pneumoniae and Escherichia coli bacteremia
1) to evaluate the effect of cART on markers of thrombophilia plasmalevels in hiv-infected patients2) to evaluate the long-term effect of cART on lipid spectrum3) to evaluate the incidence of venous thrombosis and cardiovascular events in hiv-…
To assess long-term outcomes in low-immunological risk renal transplant patients beyond one year after transplantation using tacrolimus monotherapy versus tacrolimus with mycophenolate mofetil.
To assess the effectivity and feasibility of HCV RNA self-testing in reducing the time to diagnosis of HCV re-infection in MSM previously cured of an HCV infection, compared to the current diagnostic standard of care. To evaluate whether the uptake…
The aim of this study is to determine the optimal anatomical sample site for the evaluation of CT viability by comparing the total CT load (as determined by route NAAT) and viable CT load (by V-PCR) from different anatomical sample sites.
To determine the frequency of R5-tropic N332+ viral isolates present within the latent reservoir while on suppressive ART.
To explore the effects of HBOT on immunologic parameters and oxidative stress.
The main objective is to determine the relationship between human attractiveness to mosquitoes and mosquito egg production. Secondary objectives are:* To determine the differences in human blood composition on mosquito egg production between and…
The purpose of this study is to investigate how quickly and to what extent a new tablet formulation of CG-549 is absorbed and eliminated from the body. This information will be used to select a dose of CG-549 which is expected to be safe and…
The aim is to check on current virology values (viral load (HBV DNA) and quantified HBsAg, HBcrAg, HBV RNA) to clarify if a complete return to baseline has occurred or if decreased values are still observable in patients that participated in part B…
Primary objective: To obtain insight into signature of immune responses triggered by a bivalent- or nonavalent HPV vaccination (three-dose schedule). Secondary objectives: To determine the most informative time-points to study different innate and…
The primary objective is to determine the absorption of orally administered antibiotics in patients with SBS, to guide in clinical decision making when faced with catheter related infections.
The aim of this study is to investigate the long-term immune response and determine the persistence of functional antibodies to the tetravalent MenACWY-TT vaccine administered as a second meningococcal vaccination after 5 years. This study will…