50 results
We expect that the development of mitochondrial dysfunction lags behind the development of the hypermetabolic inflammatory state. Additionally, we hypothesize that the aggravation of factors related to the hypermetabolic inflammatory status, such as…
To evaluate the role of white blood cell (WBC) scintigraphy in monitoring the response of infection treatment of a prosthetic joint infection.
Primary Objective: To determine the safety and tolerability of NF135.C10 sporozoite immunization under chemoprophylaxisSecondary Objectives:• To determine the dose-dependent protective efficacy of NF135.C10 CPS-immunization against homologous…
The objective of the study is to determine the effect of BCG revaccination and high dose BCG vaccination on the induction and course of innate immune memory.
We plan to conduct a large, pragmatic, multicentre, randomised non-inferiority trial to determine whether the use of intraoperative dexamethasone, a widely used antiemetic in perioperative medicine, is associated with an unacceptable increased risk…
The primary aim of our *Imaging of Fracture-related Infections trial (IFI trial)* is to assess the diagnostic accuracy of all commonly requested medical imaging techniques (WBC scintigraphy, FDG-PET/CT and MRI). The secondary aim is to establish…
To validate and demonstrate reproducibility of the identified sepsis CR gene signature in participants from different age groups. The validation multicenter study will also lead to biomarker refinement of the original core set of 31 genes tailored…
Primary objective:* To determine the protective efficacy of repeated short term exposure to hookworm infection Secondary objectives:1. To explore the immunological response after repeated hookworm infections2. To evaluate the safety of and number of…
(1) To determine the presence of T. pallidum DNA as proxy for the infectiousness of peripheral blood, urethral, anal and pharyngeal mucosa in infectious syphilis. (2) To evaluate T. pallidum polymerase chain reaction test (Tp-PCR) to diagnose…
The objective of this study is to determine the incidence of chronic Q fever and seronegativity in vascular patients that were seropositive after the Dutch Q fever outbreak. Seropositivity can indicate a past resolved Q fever infection or chronic Q…
Aim of the MIRRE pilot study is to determine how much the primary inoculation dose of diarrheagenic E. coli should be lowered in order to result in a reduced protective response upon a secondary infection.
To evaluate the inflammatory reducing effect, in the periodontal tissues and systemically, of vitamin C with quercetin and other flavonoids in untreated periodontal disease. Secondly to evaluate the effect of vitamin C with quercetin and other…
To deliver proof of concept that antifungal prophylaxis with posaconazole in addition to standard of care (SOC) can reduce the incidence of IAA in ICU patients with severe influenza, in comparison with SOC alone.To assess differences in cytokine…
The primary objective of this study is to compare the safety, overall tolerability, and virologic response of BCV vs. SoC (i.e., investigator-assigned therapy) for the treatment of AdV infection in high-risk pediatric allogeneic HCT recipients. A…
To clarify the pathophysiological genetic pathway of the association between C. burnetii and NHL
Primary objectives: 1. . To study prevalence of NASH in unselected HIV-monoinfected patients assessed by Fibro scan. Secondary objectives:2. To identify risk factors for NASH in HIV infected patients compared to HIV-positive patients without NASH. 3…
We aim to validate cellular tests to determine their value in diagnosing LB, as well as to describe the potential added value of these tests in the setting of a specialized Lyme center.
Compare PRF and EMD regenerative potential in the surgical treatment of molar teeth with periodontal destruction in the furcation area.Evaluate induced Healing potential of the two materials. Correlate healing pattern with biomarkers in blood and…
The purpose of this pilot study is to determine the optimal timing to replace a catheter in patients with an indwelling catheter and systematic symptoms of an UTI.
1. To estimate the incidence and severity of fungal infections during anti-Th17 mAb therapy2. To characterize the determinants (clinical, immunological, mycobiome/microbiomeand genetical) for developing fungal infections during anti-Th17mAb therapy…