84 results
Primary objectives:1) To evaluate the safety of four different CHMI-trans protocols in healthy malaria-naïve volunteers challenged with Plasmodium falciparum by sporozoite challenge. 2) To determine the best CHMI-trans protocol for induction of…
To investigate the safety of the vaccination and the immune responses generated by the different formulations and dosing regimens of FLU-v in healthy adults.
This study aims to identify global and local determinants of HPV vaccine acceptability, HPV vaccine uptake and compliance as well as identify logistics and programmatic issues in each country to offer the HPV vaccine, as a potential cervical cancer…
This research project aims to determine the feasibility of setting up a randomized controlled trial to study the effects of different fluid management protocols on the outcome of mechanically ventilated pediatric patients with acute infectious lung…
The primary objective of this study is to investigate whether FMT after antibiotic therapy is more effective than conventionalantibiotic therapy alone in patients with a first episode of CDI.
The purpose of this study is to provide insight in to what extent clinically significant systemic absorption of tobramycin occurs (resulting in a serum tobramycin concentration> 1.0 mg / L) in ICU and Medium Care ICU patients who are being…
To document that 8 weeks treatment with ledipasvir-sofosbuvir is effective in chronic HCV genotype 4 patients without cirrhosis.
1. Determine whether different classes of epigenetic modifiers affect HIV-1-specific T cell immunity.a. Investigate whether HIV-specific T cell exhaustion can be reversed by inhibitors of different classes of epigenetic modifiers.b. Examine whether…
The primary objective is to determine the safety and tolerability BCG vaccination followed by controlled human malaria infection; and to determine the protective efficacy BCG vaccination against a controlled human malaria infection.
The aim of this study is to analyze the long-term effect of full-mouth tooth extraction on the oral microflora, using the 16S next-generation sequencing technique.
a pilot study will be performed to gain understanding in cognitive functioning in patients with chronic Q-fever or QFS compared to matched controls.
To gain insight in the pharmacokinetics of sinecathechins ointment 10% (Veregen) applied on healthy skin, using Raman micro-spectroscopy and chromatography of tape strips.
To investigate the pathophysiological link between RA and PD, and test the efficacy of RvE1 treatment in gingival tissue biopsies of RA-PD and RA risk-PD patients ex vivo.
Objective of the study is to evaluate efficacy of VZV vaccination in lung transplantation patients, intended to prevent morbidity by VZV infection. Efficacy of vaccination will be measured by means of determining cellular immunity to VZV. Cellular…
Primary objective:To determine whether endotoxin tolerance can be prevented by acetylsalicylic acid prophylaxis or can be reversed by acetylsalicylic acid treatment, expressed as an augmentation of pro-inflammatory cytokine levels during the second…
Aim of the current study is to evaluate the effect of lactoferrin on the innate immune response in elderly in a pilot study. Furthermore, support of this effect by GOS and Vitamin D will be studied.
The primary objective of this randomized controlled trial is to compare the clinical effect of decontamination of the implant surface during the non-surgical treatment of peri-implantitis using air polishing or ultrasonic treatment. Secondary…
Primary objective:To determine the incidence of Clostridium difficile infection (CDI) in hospitalized patients aged * 50 years old and receiving oral or intravenous fluoroquinolones, cephalosporins, penicillins + beta-lactamase inhibitors,…
This study will investigate the value of C. burnetii-specific whole-blood IFNγ and IL-2 production assays in QFS patients that have either recovered, or are still substantially fatigued. This will show us if these assays can serve as potential…
Primary endpoint: Evaluation of the safety of the novel anti-TB vaccine RUTI® (25*g FCMtb) in patients with MDR-TB favourably responding to second-line, standard MDRTB treatment through clinical, microbiological, and radiological response criteria.…