81 results
To study phenotypic and functional characteristics of hepatic lymphocytes in patients with viral hepatitis or other liver related diseases.
1. To establish whether serial exhaled breath analysis using eNose can detect invasive pulmonary aspergillosis in patients with prolonged chemotherapy induced neutropenia (neutrophil counts <0.5 x 10^9 for more than 7 days).2. To establish…
Primairy objectivesTo study the pharmacokinetics (plasma and cerebrospinal fluid) of meropenem in infants <= 90 days of postnatal age with probable or confirmed bacterial meningitis (BM); To describe the safety profile of meropenem in the…
To determine whether (supplemental) human donor milk has beneficial effects (in terms of reduction of infectious episodes and mortality) when compared to (supplemental) preterm formula during the first 10 days of life in VLBW infants. Amendement ESS…
To explore the association between MBL level at baseline and the incidence of febrile neutropenia.
- To assess the burden of disease of congenital CMV infection in the Netherlands at the age of 5 to 6 years through the assessment of the occurrence of sensorineural hearing loss due to congenital CMV infection.- To establish the burden of disease…
Primary objective: To investigate whether pharmacokinetics of the recommended dose of inhaled tobramycin, defined as serum tobramycin Area Under the Curve (AUC0-24hr), with the I-neb (75 mg) is equivalent to the PariLCPlus (300 mg) nebuliser in…
The primary objectives of this study are:* To determine the efficacy of GS-7977 + RBV with or without Peginterferon alfa-2a (PEG) as measured by the proportion of subjects with sustained viral response at 12 weeks after discontinuation of therapy (…
Primary objective:To evaluate the efficacy of a RPV based HAART in patients that switch from NVP with FTC, TDF or lamivudine (3TC), TDF or 3TC, zidovudine (ZDV) to RPV/FTC/TDF.Secondary objectives:To measure the impact (strength and duration) of NVP…
The aim of this study is to determine whether Staphylococcus aureus colonizes the human throat and the perineal area independent of the nose.
Establish the pharmacokinetic parameters of micafungin in critically ill patients and determine whether pharmacokinetic parameters and plasma concentrations of micafungin correlate with disease severity.
Primary Objective:This research study is designed to assess the effectiveness of the combination of study drugs (ASV + DCV) being used to treat the hepatitis C virus (HCV). The best way to assess this aim is to measure the amount of virus in…
Enhancement of the sensitivity of the Quantiferon test for patients with an inflammatory disease who are screened for presence of latent tuberculosis infection.
Patients with chronic diseases require long-term adherence. Adherence can be improved by patient counseling as is common in disease management programs. However, personal counseling is expensive, especially given the fact that chronic patients will…
The main objective is to study the impact of cross-reactivity by other flaviviridae (Yellow Fever virus, Tick Born Encephalitis virus, West Nile virus, Japanese Encephalitis virus and Hepatitis C virus) on Dengue IgG serology using enzyme-linked…
Clarifying the qualitative and quantitative aspects of the T cell response targeting and controlling polyomavirus BKV.
The primary objectives of this study are as follows:• To determine the efficacy of treatment with GS-7977+ribavirin (RBV) compared as measured by the proportion of subjects with sustained viral response 12 weeks after discontinuation of therapy (…
The primary objective of this study is to evaluate the safety and antiviral efficacy, defined as the percentage of subjects with sustained virologic response 12 weeks post-dosing (SVR12; HCV RNA < LLOQ 12 weeks after the last dose of study…
The aim of this study is to find out whether TIG and revaccination prescription is in accordance with the immune status of a patient as measured by the TQS. Furthermore, the objective is to assess whether or not the TQS might be of additional value…
Primary ObjectiveTo assess the efficacy based on the proportion of subjects with SVR12, defined as HCV RNAgenotype 1 who are prior non-responders to pegIFNα-2a/RBV.Secondary Objectives• To assess efficacy, as determined by the proportion of subjects…