94 results
To evaluate in detail the functionality of immune cells in the liver and blood in chronic HCV patients before, during and after treatment with telaprevir, pegylated-IFN-alfa and ribavirin.
The primary objective is to evaluate the antiviral efficacy of TMC435 in combination with PegIFN*-2a and RBV.In addition to this, the study provides access to TMC435 treatment in combination with PegIFN/RBV to (1) subjects whoparticipated in the…
The primary objective of this study is to explore if (and which) HIV-specific CTL responses shorten the lifespan of productively infected cells in HIV-infected individuals. This will be accomplished by investigating the estimated life spans of…
First, to explore relationships between immunological factors (cytokines and chemokines), psychological stress, and pain, controlled for infection. Second, to explore relationships between immunological factors (MBL), bacterial colonisation and…
The primary objective of this study is to evaluate the efficacy of TDF plus Peginterferon *-2a (PEG) combination therapy for 48 weeks versus standard of care TDF monotherapy or PEG monotherapy for 48 weeks in non-cirrhotic CHB subjects as determined…
To study the immunogenicity and safety of adjuvanrt hepatitis B vaccin (Fendrix) compared to double-dosage of Engerix vaccination in HIV infected patients, previously failing HBV vaccinations.
Primary objectives:1. To determine the effect of the use of a tailored intervention protocol (regarding reduced antimicrobial use, improving hygiene and changing the animal contact structure) on pig and veal farms on the degree of antimicrobial…
The primary goal of this study is to determine if the use of multi-site NIRS-monitoring in newborn infants at risk of circulatory failure could lead to a better diagnosis, treatment and outcome in these infants compared to the use of conventional…
The primary objective is to elucidate the question whether historic HBV viral load (in samples taken from 1989 * 1996 during pregnancy) is associated with the risk of HBV-related cirrhosis or mortality in a cohort of non-Asian individuals with…
The aim of this study is to create a prognostic model enabling the clinician to predict the outcome of a septic episode. Furthermore, by getting more insight in the pathophysiologic proces of sepsis, we could discover new possible targets for future…
Primary: To assess the effect of multiple oral doses of 600 mg efavirenz once daily on the PK of BMS-790052 at steady state in healthy subjects.Secondary: To assess the safety of multiple oral doses of BMS-790052 given alone and together with…
To assess the safety, reactogenicity, and tolerability of increasing GEM intranasal doses (1.25 mg, 2.5 mg and 5.0 mg) and intramuscular doses (0.05, 0.1, 0.2 mg) of the GEM adjuvant, each administration containing as well a standard 2010/2011 Flu…
Primary objective: To investigate whether CPS immunization confers protection to a blood stage challenge.Secondary objectives: • To study and compare parasitemia after challenge between study groups• To analyze and compare the immune responses…
To asess whether the Chlamydia Antibody Test (CAT), used to determine the presence of antichlamydia IgG antibodies in serum for diagnostics in the fertility clinic, can serve as an intermediate marker for PID/tubal pathology caused by Chlamydia.
Primary objective: To determine if a single administration of SRT2379, at multiple dose levels, attenuates the inflammatory response in normal healthy male subjects after exposure to low-dose endotoxin (LPS)Secondary objectives: (1) To determine…
The aim of this study is to explore the prevalence of HAND in people living with HIV.
Primary objectiveTo determine the effect of multiple dose OME on the pharmacokinetics (AUC0-8h, Cmax, C8h) of BOC.Secondary objectives:To determine the effect of steady state BOC on the pharmacokinetics (AUC0-8h, Cmax, C8h) of multiple dose OME.To…
We will investigate whether Chlamydia IgG antibody presence and titers in vaginal swabs (mucosa-CAT) are comparable to antibodies found in serum (serum-CAT), and as such could serve as a marker for a past Chlamydia infection with an enhanced risk of…
The objective of this study is to gain insight in HIV infected children in the AMC in:.- the prevalence and clinical signs of livertoxicity - an association between the different compounds of combination anti-retroviral therapy (cART) and…
To assess the efficacy of two treatment strategies for fatigue and disabilities in QFS: long term treatment with doxycycline or cognitive behavioral therapy (CBT).