75 results
To investigate the use of a temporary peginterferon alpha-2a add-on strategy during entecavir therapy in patients with HBeAg-positive chronic hepatitis B by comparing the efficacy of this regimen versus entecavir monotherapy.To evaluate the long-…
1. To decrease the proportion of infants treated with antibiotics for > 48 - 72 hours with possible or unlikely infection, with unchanged outcome. 2. To reduce the duration of antibiotic therapy
The objective of this study proposal is to determine whether pharmacologic optimization of voriconazole by means of therapeutic drug monitoring (TDM) results in improved patient outcomes (efficacy and safety) and is more cost-effective compared to…
To protect children with hiv and children using immune-suppressive medication against hepatitis A and B, and to determine the immunogenicity of the combined hepatitis A and B vaccine in these children.
To study the relationship between (a) abnormal concentrations of plasma amino-acids, pterins, HVA and inflammatory parameters and (b) the severity, duration and outcome of delirium. To find a biochemical profile that predicts the occurrence of a…
The purpose of this trial is to evaluate whether procalcitonin measurements are able to reduce antibiotic usage in Dutch intensive care units by reducing the duration of antibiotic treatment.
To study if there is a role for prophylactic VZV vaccination prior to transplantation to boost the patients B- and T-cell repertoire and thereby reducing the incidence and morbidity associated with herpes zoster.
If proven (cost)effective, without inducing antivral resistance, oseltamivir could have considerable benefits in this setting, although constraints relating to implementation need to be addressed as well. If not (cost)effective if this fragile…
To assess the prevalence of HIV, hepatitis C and B, and (related) risk behavior among hard drug users in care at Mondriaan carecentre for addiction in Heerlen.
The primary objective is: To evaluate the efficacy, safety and tolerability of NIM811 administered in combination with SOC in an interferon-relapser population of patients infected with chronic hepatitis C genotype-1.Secundary objectives are: * To…
To assess the efficacy of treatment with monochloroacetic compared to treatment with cryotherapy regarding patients with handwarts and compared to combination therapy (salicylic acid and cryotherapy) regarding patients with plantar warts.WARTS-1 has…
Primary objective: To evaluate the influence of fosamprenavir/ritonavir on single-dose pharmacokinetics of olanzapine in healthy volunteersSecondary objective: To evaluate the safety of fosamprenavir/ritonavir combined with single-dose olanzapine in…
To assess the prevalence of HIV, hepatitis C and B, and (related) risk behavior among hard drug users in care at Mondriaan carecentre for addiction in Heerlen.
Is the duration of Procalcitonin guided antibiotic therapy shorter than standard antibiotic therapy in patients with sepsis admitted to the ICU and treated with antibiotics
Primary objective: To determine the dynamics of MRSA carriage in persons working on or living at pig and veal farms.Secondary objectives: To determine the amount of disease associated with carriage of MRSA-CC398. To determine the role of exposure to…
This study is being conducted to provide performance evaluation data for the cobas 4800 CT/NG Test. This data will be used as part of the cobas 4800 CT/NG Test CE submission package. Comparison with a 'state of the art' technique (Abbott…
The primary aim of this study is to determine the utility of measurement of CMV specific cell mediated immunity using the Quantiferon-CMV assay for predicting the risks of CMV infection and disease in D+/R- SOT recipients after the completion of…
Primary: To assess the antiviral efficacy of triple combination antiviral drug (TCAD) therapy(i.e. amantadine and ribavirin co-administered with oseltamivir) compared to oseltamivirmonotherapy in immunocompromised subjects diagnosed with Influenza…
Primary Objectives: • To determine the basic immunity against influenza H1N1 (2009) in the population.• To determine the humoral and cellular immunity after a single vaccination with Influenza A virus (H1N1) 2009 Monovalent MF59- Adjuvanted Vaccine…
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