26 results
The primary objective is acquiring insights in the development of BOS in patients after human lung transplantation in an early phase of the disease which can be used to improve immunotherapeutic handling in order to prevent or delay the onset of BOS…
* To demonstrate efficacy of the candidate vaccine in the prevention of (1) persistent infection (6-month definition) with HPV-16 or HPV-18 (by polymerase chain reaction [PCR]) and/or (2) histopathologically-confirmed CIN1+ associated with HPV-16 or…
The primary hypothesis of our study is that volumetric monitoring will allow for more effective and targeted fluid administration compared to pressure (PAC) monitoring, thereby allowing the attending physician to better optimize fluid infusion…
The primary objective of this trial is to provide early access to TMC125 for treatment-experienced HIV-1 infected patients who have failed multiple ARV regimens and have limited treatment options with the currently approved antiretrovirals.The…
The primary objective of this study is to demonstrate the superior antiviral efficacy of the combination of peginterferon alpha-2a plus telbivudine vs peginterferon alpha-2a monotherapy as demonstrated by HBV DNA non-detectability using the COBAS…
Primary objective:- To evaluate dose modifications of the new Kaletra Meltrex tablets (lopi-navir/ritonavir 200/50 mg) when combined with rifampicin in healthy volunteersSecondary objectives:- To evaluate the safety of combined use of the new…
Primary aimTo evaluate the effects of peginterferon and ribavirin therapy on the immune response in chronic HCV genotype 1 patients before, during and after treatment.Secondary aims1. To determine if differential modulation of Treg activity or DC…
Establish relevance of a clinical scoring system, and of established and to be identified biomarkers in blood and urine for clinical course and clinical and microbiological outcome of patients with a complicated urinary tract infection, treated in…
How long does B-cell memory persist after a single conjugate MenC vaccination and which cells are involved? How is this related to the age of first vaccination? And how to define correlates of protection for immunity and memory after MenC conjugate…
To determine whether tobramycin, administered in the gut, permeates from the gut into the blood and is subsequently excreted into the urine.
To investigate the gene and protein expression of neonates suffering from CoNS late-onset sepsis.
Objectives* The primary aim is to study the kinetics of QFT-G in military personnel with a positive TST result. * Secondary aims are to study the practical feasibility of using QFT-G in the setting of a military hospital.Next to this we wish to…
The primary objective of this study is to evaluate the efficacy of SCH 503034800 mg TID PO in combination with PegIntron 1.5 *g/kg QW SC plus ribavirin (800 - 1400 mg/day) in previously untreated adult chronic hepatitis C (CHC) subjects infected…
The expectation is that FDG-PET demonstrates or excludes infectious complications earlier than current practice, resulting in more efficient use of other diagnostic methods and therapy. Besides early detection and treatment of invasive fungal…
The general objective of this study is to elucidate the cellular components for HIV-1 infection in children.
The objective of this study is to evaluate the concentrations in blood after a single administration of 100 mg TMC125. The various administration formulations will be compared to demonstrate that the formulations can be exchanged. The administration…
1. To gain insight into the prevalence and incidence of HIV and other sexually transmitted infections and blood borne infections among visitors of the STI clinic in Amsterdam.2. To gain insight into risk factors and risk behaviour among visitors of…
To determine the occurrence and variety of viral respiratory infections and their associated morbidity in the elderly and their care-takers.
To study the pharmacokinetics of linezolid in MDR-TB patients, specifically in the relationship to dose, treatment duration and toxicity.
To make a risk estimation of the risk for public health, research is needed about:1. How many Ae. Albopictus are being introduced in the Nederlands?2. Does Ae. albopictus settle permanently in the Nederlands? If yes, where?3. Do the imported…