88 results
Primary Efficacy Objective:• To evaluate the efficacy of tocilizumab (TCZ) compared to placebo, in combination with a26-week prednisone taper regimen, in patients with giant cell arteritis (GCA), as measured by the proportion of patients in…
To determine the frequency of MBL and FCN SNPs in patients with a history of a proven gram-positive bacteremia, compared to patients without such history. A secondary objective is to determine whether extracorporeal circuits, used in cardiothoracic…
To find out if intravenous MSC is a safe treatment for children with therapy-resistant JIA
Primary: Safety and tolerability of fingolimod 0,5 mg.Secundairy: Efficacy and quality of life.
To demonstrate that food elimination therapy based on component-resolved diagnostics is an effective and acceptable treatment for EoO patients.
to combine and validate diagnostic tests for the prediction of clinical response to therapy with biologics in patients with reumatoid artritis.
Evaluation of therapeutic safety and clinical efficacy of MSC transplantation in septic shock.
to combine and validate diagnostic tests for the identification of preclinical very early RA (VERA) patients and prognostic tests for the prediction of progression
- Primary objective: The effect of C1-INH prior to induction of a systemic inflammation by endotoxin (E. coli lipopolysaccharide), on the leukocyte phenotype, activation and mobilization. - Secondary objectives: - Determine the effect of C1-…
The aim of the study is to test the hypothesis that susceptibility to and severity of certain infectious and inflammatory diseases can be explained by the interaction between the genome, microbiome and immunological responses: i.e. presence of…
Primary Objective: To objectify the innate immune response to acute and prolonged exercise and get insight in this response over time (hours). Secondary Objective(s):- Investigate the nature of the post-exercise leukocytosis- Which leukocytes appear…
Primary Objective: To determine minimum and non-provoking doses of soy protein (in mg) for soy allergic individuals Secondary Objective(s): To determine the relevant allergens of soy in soy allergy and to determine the relation between allergen…
Primary objective:Pharmacokinetics/-dynamics of 124I-F8IL10 Secondary objective:Dosimetric parameters of arthritic joints and internal organs.
to combine and validate diagnostic and prognostic tests for patients with recently diagnosed rheumatoid arthritis to predict joint damage and response to (DMARD) therapy.
The aim of this study is to investigate immune response to pneumococcal vaccination in patients after community acquired pneumonia with S. pneumoniae compared to pneumonia patients with another pathogen.
- To study the clinical characteristics and disease course of patients with LEMS with or without SCLC- To identify the characteristics of the humoral or cellular immune response that are associated with the prolonged survival of patients with SCLC…
The objective of this study is to explore the efficacy and safety of gevokizumab in patients with Schnitzler syndrome.
Primary Objective: To determine for a series of drugs frequently used perioperatively the maximal non irritative concentration in intracutaneous skin testing in healthy volunteers. Secondary Objective(s): To compare the percentage/number of positive…
To investigate the impact of high field 3T MRI on the diagnostic criteria in MS in a large multicenter study population using multiple vendor MRI systems.
The primary objective of the study is to assess whether ixekizumab 80 mg every 2 weeks (Q2W) or80 mg every 4 weeks (Q4W) is superior to placebo in the treatment of biologic disease-modifying antirheumatic drug (bDMARD)-naive patients with active…