37 results
To evaluate whether doxepin hydrochloride 5% cream is more effective in reducing pruritus in burn patients than standard treatment (clemastine).
To evaluate the effectiveness, cost-effectiveness and quality of life of Flaminal® versus Flammazine® in the treatment of superficial and deep partial thickness burns.
The main objective of this study is to assess perfusion of the foot and correlate perfusion values with arterial patency. To this end, first the PCT protocol of the foot in patients with CLI needs to be optimized in terms of contrast dose…
Are Alphabodies against IL23 effecive in the transplant model of psoriasis
Primary: (part 3) Potential of BPR277 1% ointment b.i.d. to improve the clinical severity of lesional skin in the majority of NS patients at end of treatment versus baseline of >= 2 points, dose range and regimen relationship on clinical…
Is CMPX-2030 effective in the transplant model of psoriasis
To investigate the possibility to measure non-invasively perfusion and oxygenation in static physiological conditions in the lower leg using MSOT.
In this study the effect of a novel compound on the development of psoriasis in the humanized mouse model is investigated. In addition, the material of 3 donors wil be used to develop the mouse model further and train technicians. The focus will be…
Client wishes to see if HPP-A is active in the transplant model of psoriasis
Primary objectivesTo study the relation between the physiological, microbiological and immunological status of the skin and the response to an external stimulus; to assess:• the relations between microbiome and/or immunology and the skin type;• the…
The primary objective is: The minimum time in days after treatment for Ng to perform a TOC using NAAT and DNA PCR. Secondary objectives are: Time to clearance per infected location. Host and pathogen related factors associated with time to clearance…
Primary objective: To evaluate the efficacy of once daily doses of QAW039, as measured by EASI after 12 weeks of treatment, relative to placebo, in adult patients with moderate to severe AD. To evaluate safety and tolerability.Secondary objectives:…
The main objective of our study is to examine whether there is an association between IT (as determined by visual irritation grading scale after SLS patch test) and HTS formation and whether IT is a good predictor for HTS formation. If so then this…
Because the pathophysiology of SSc is unknown, there is currently no treatment available to cure the disease itself, so only individual organ system complications are treated (7,8). Therefore, treatment is patient-specific and aimed at ameliorating…
Primary Objective: Investigate whether early valganciclovir treatment of children with SNHL of * 20 dB, unilateral or bilateral, and a confirmed congenital CMV infection can prevent deterioration of the hearing loss at follow-up (age 18 * 22 months…
We propose a phase II study (intervention) in patients with severe generalized recessive dystrophic EB receiving reduced toxicity conditioning chemotherapy followe by cord blood transplantation with co-infusion of mesenchymal stromal cell units.…
Primary: To demonstrate the superiority of secukinumab in subjects with moderate to severe plaque psoriasis based on the proportion of PASI 90 responders at Week 16, compared to ustekinumab.Secondary: To demonstrate the superiority of secukinumab in…
The main objectives of this study are to investigate 1) in vivo dermal absorption of Ag ions from the Silverwear ® garments in healthy versus atopic skin, 2) effect of dermal exposure to Silverwear ® garments on release of inflammatory cytokines in…
Primary research question:Will the use of Aquacel Ag Surgical as a postoperative wound dressing result in less postoperative wound infections?