159 results
The objective of this cross-sectional study is to assess the relation between plaque characteristics, detected by Coronary Computed Tomography Angiography (CCTA) and Intravascular Optical Coherence Tomography (IVOCT), and the hemodynamic…
Primary objective:• To investigate whether Enhanced programming is safe for primary and secondary prevention patientsSecondary objectives:• Investigate the impact of Enhanced programming on adverse events (related to ICD shock with consequences and…
In this study we aim to investigate whether infusion of intestinal microbiota from lean (vegetarian) donors has differential effect on choline (d6-labeled choline) and carnitine (d3-labeled carnitine) metabolism and macrovascular inflammation (18F-…
The objective is to collect additional data on the clinical outcomes (surgical data, safety and clinical performance) of the Medtronic Enable® Aortic Bioprosthesis in *real world* patients. The collected data will be used to improve aortic valve…
The overall objective of this study is to increase the uptake and maintenance of healthy behaviors among adults from non-Western immigrant populations who are identified as having a high risk of cardiometabolic disease after completing a health…
The primary objective of this study is to test the hypothesis that evacetrapib 130 mg daily, in comparison to placebo, reduces the incidence of the composite endpoint of cardiovascular (CV) death, myocardial infarction (MI), stroke, coronary…
The primary objective is to evaluate the safety and efficacy of the PulseCath iVAC2L in highriskPCI patients who require left ventricular assistance. Safety will be assessed by theincidence of Cerebrovascular Accidents (CVA*s), thrombo-embolic…
Predicting fluid responsiveness during PLR and fluid challenge (FC) by changes in (Pms).
Primary objective:To assess the two-year prevalence and incidence of clinical relevant arrhythmias in drug-resistant epilepsy.Secondary objective:To assess whether the recorded cardiac arrhythmias are related to epileptic seizures (subjectively from…
The primary objectives of this study are to select an oral modified release (MR) formulation and dose of omecamtiv mecarbil for in subjects with HF and left ventricular systolic dysfunction and to characterize itspharmacokinetics (PK) after 20 weeks…
To investigate the risk of deeath and incident (cardio)vascular disease in patients with a TIA or stroke aged 18-50 yearsTo investigate the riks of cognitive impairment and (vascular) dementia in patients with a TIA or stroke aged 18-50 yearsTo…
The study objective is to assess the safety and efficacy of the Svelte Drug-Eluting Coronary Stent Integrated Delivery System (IDS) compared to the Resolute IntegrityTM Drug-Eluting Stent in patients with single, de novo coronary artery lesions.
1) To investigate the differences in lipid content of the plaques after placement of a Stentys self-apposing stent. 2) To investigate whether there is a correlation between the decrease lpid-core content and the increase in cardiac biomarkers (…
The primary aim of this observational study is to determine the occurrence of exercise-induced left ventricular diastolic dysfunction (LV-DD) in symptomatic COPD patients with a normal echocardiography at rest. And, secondly, to study the…
The present study protocol proposes a novel cGMP Enhancing Therapeutic Strategy (cGETS) to 1) enhance plasma levels of cGMP, 2) to increase cGMP-related control of the myocardial response to low dose dobutamine stress testing, 3) to improve…
To further study the safety and effectiveness of the MitraClip system in the treatment of clinically significant functional mitral regurgitation in patients with New York Heart Association (NYHA) Functional Class III or Class IV chronic heart…
To assess the safety and effectiveness of the SYNERGYTM Coronary Stent System for the treatment of subjects with atherosclerotic lesion(s) * 34 mm in length (by visual estimate) in native coronary arteries *2.25 mm to *4.0 mm in diameter (by visual…
The main objective in this study is to determine whether there is an effect of acute unloading of the left ventricle on the ECG, in particular the T-wave.
To test the non-inferiority of 6- versus 12- month dual antiplatelet therapy in patients with lesions treated with at least one second generation DES.
The objectives of this study are to evaluate cardiac performance characteristics and adverse events rates associated with the EDWARDS INTUITY Valve in patients undergoing aortic valve replacement (AVR). The AVR surgical approach is either full or…