33 results
The family with the TRα2 premature stop enables us to investigate the biological role of the orphan wild-type TRα2 and the consequences of its dysfunction. The primary objectives of this proposal are (i) to search for a biological function of TRα2…
Primary Objective: To characterize the long-term safety and tolerability of AMG 416 in the treatment of SHPT in subjects with CKD on hemodialysisSecondary Objective: To characterize the long-term efficacy of AMG 416 on intact parathyroid hormone (…
This study aims to detect differences in sick leave time, associated costs and quality of life between differentiated thyroid cancer patients treated in either a fast-track protocol or a traditional longer time interval between total thyroidectomy…
Next to cardiovascular risk factors (main objectives: body composition and lipid profile; secondary objectives: remainder) we investigate the effect of GH treatment on glucose metabolism, physical performance, and neuropsychological functioning of…
To find out if the mean thyroid volumes of healthy 10-12 and 17-18 years old Dutch children and adolescents are the same or larger than in the late nineteen nineties, and if the dietary iodine intake of these children and adolescents has decreased…
To determine the value of multimodality image registration of cone-beam CT (CBCT) and CT in increasing the success rate of adrenal vein sampling procedure compared to procedures without CBCT guidance.
Primary objective is: - To evaluate the effects of dehydration and subsequent rehydration on coagulation and fibrinolytic parametersSecondary objectives are:- To evaluate whether the response of coagulation and fibrinolytic parameters to fluid…
Primary Objectives 1. To assess whether radioiodine therapy results in hyposalivation, altered saliva composition and xerostomia in DTC patients.2. To assess whether the extent of radioiodine uptake on the pre- and post-therapy WBS and SPECT/CT is…
To evaluate the efficacy of pasireotide LAR and everolimus alone or in combination in progressive patients with a well differentiated neuroendocrine tumor of the lung or thymus.
1. To explore the validity and usefulness of Bone Microindentation Technique (BMT) in the assessment of bone quality in patients with osteoporosis and a spectre of bone diseases characterised with (localised) increased bone turnover. 2. To study the…
We aim to investigate whether a relation between intestinal microbiota composition, mucosal integrity and translocation of bacteria into adipose tissue of the affected eye is related to the severity of Graves orbitopathy.
This is a protocol aimed at standardizing clinical care and the diagnostic approach in a carrier of a pathogenic IGSF1 mutation referred for hormonal analysis to the outpatient clinic.
1. Does Levothyroxine treatment for subclinical hypothyroidism give multi-modal benefits for the oldest old people with subclinical hypothyroidism?2. Are benefits seen across a wide range of outcomes, including prevention of cardiovascular disease,…
Objectives: Part 1) To assess the prevalence of PA in general practice (part 1 of this study);Part 2) To describe differences of cardiorenovascular damage in newly diagnosed hypertensive patients with versus without PA (part 2 of this study);Part 3…
Objective: Main objective of this study is to compare the area under the MPH saliva concentration versus time curve (AUC) following ingestion of immediate and sustained release formulations of MPH in children with ADHD. Secondary objectives are: 1.…
Primary objective: To determine the efficacy of Sunitinib on the progression-free survival at 12 months in subjects with progressive malignant pheochromocytoma and paraganglioma treated with sunitinib at a starting dose of 37.5 mg daily (continuous…
Study the mechanisms of BAT activity and the effects of BAT acitivity on energy homeostasis.
Our primary objectives are:- to estimate the prevalence of central adrenal insufficiency , defined as a plasma cortisol response <500 nmol/l in the low-dose ACTH test (see paragraph 8.3.5 of the protocol). - to describe immune dysfunction, i.…
To increase insight in the glucose metabolism in surgically treated PPGL patients by using dynamic FDG-PET/CT for analysis of tumor metabolic activity, blood fraction and full pharmacokinetic parameters. Furthermore, to correlate these finding with…
Primary objective:* Demonstrating clinical superiority of MOD-4023 compared to placebo in terms of reduction of fat mass (FM) in adults persons with GHDSecondary objectives:* Determining the efficacy of MOD-4023 compared to placebo in other body…