273 results
In the current study, we want to determine and correlate the results of both perfusion capacity (with MR imaging) and sublingual glycocalyx dimensions in a) patients with proven obstructive coronary artery disease and b) patients with angina but…
5.1 Study ObjectivesThe primary objective for this clinical observational study is to assess the role of the Sapheon Closure System in closure of incompetent great saphenous veins in a routine clinical setting.5.2 Study HypothesisThis is an…
The research focuses on the active screening of high prevalence patients and the diagnosis of AAA. This study aims to establish an effective screening protocol and determining a higher prevalence in patients with PAD and patients with carotid…
Our overall objective is to better understand the role of regulatory B cells in disease pathogenesis and to better predict disease flares in order to individualize treatment.
Primary objective:- Determining the extent to which perfusion territories of the larger intracranial arteries are affected by endovascular treatment of intracranial aneurysmsSecondary objectives:- Defining the relationship between collateral…
The principal aim of this study is to examine whether glycocalyx volume, as estimated by SDF-imaging, is associated with cardiovascular risk as estimated by conventional risk scores.
1a) To determine the prevalence of digital pathology, possibly as a result of digital emboli, in the dominant hand in symptomatic and asymptomatic elite Dutch male volleyball players. 1b) To determine the association between the presence of digital…
Our primary objective is to determine the effect of breast reconstruction on the risk of developing lymphedema. Secondarily, we will look at lymphedema and the correlation with 1) primary and secondary breast reconstruction, 2) the extent of…
The aim of this proposal is to investigate the potential use and value of experienced utility, as measured by the ESM and the DRM, in the economic evaluation of health care.Research question:1. What are the differences between the utilities measured…
The primary objective of this study is to examine the determinants of health behavior intentions and changes in patients with TIA or ischemic stroke, and the effects of age, sex, and cognitive and functional status on these determinants as well as…
The primary goal of this study is to determine if the use of multi-site NIRS-monitoring in newborn infants at risk of circulatory failure could lead to a better diagnosis, treatment and outcome in these infants compared to the use of conventional…
Our aim is to determine a Pharmacokinetic/Pharmacodynamic (PkPd) based dosing model for nicardipine used for treatment of severe hypertension in preeclamptic patients. The model is based upon determination of maternal, fetal and neonatal plasma…
Effect of SCS on CBF
To investigate whether 7T 31P magnetic resonance spectroscopy (MRS) provides an objective method to assess metabolic changes in response to ischemia in calf muscles of patients with critical limb ischemia (CLI) compared to healthy controls.Research…
To assess the additional prognostic value of combined CTP and CTA parameters to baseline patient criteria and plain CT. Secondary objective is to subsequently use the best CTP and CTA indicators of outcome of infarct in a prediction model for…
To describe the differences in macrophage infiltration and mRNA expression of adipocytokines in subcutaneous, omental and perirenal fat tissue in Cushing's syndrome compared to healthy controls.
This quantitative research project was preceded by a qualitative study (Sexuality in people with a limb amputation and their partner: a qualitative study; METc 2010/179). The aims of the current study are to explore:- which sexual problems occur in…
Primary objective:- To obtain reference values for arterial stiffness, measured as PWV and AIx, and insulin resistance, calculated as HOMA-IR in normal weight, healthy adolescents in different Tanner stages.Secondary objectives: - To determine the…
Objectives: Part 1) To assess the prevalence of PA in general practice (part 1 of this study);Part 2) To describe differences of cardiorenovascular damage in newly diagnosed hypertensive patients with versus without PA (part 2 of this study);Part 3…
This study has two principal aims. The first aim is to establish the relation between the auto-cuff response and target organ damage defined as difference in microalbumin/creatinin ratio. The second aim is to assess the difference in BP between…