84 results
to identify novel molecular pathways resulting in premature atherosclerosis (PAS) in families where the traditional risk factors are not present / near absent.
A study to explore three different diagnostic tools (predictors) (tcPO2 measurement, BOLD MRI and DCE MRI) quantifying the degree of tissue perfusion and oxygenation at the intended amputation level in patients with refractory critical limb ischemia…
To determine the within and between variability of pharmacokinetic (PK) profiles in patients treated with DOACs in daily practice
* To investigate whether it*s feasible to detect within the carotid artery the carotid plaques using optoacoustic imaging with the innovative MSOT Acuity Echo in patients with symptomatic carotid stenosis. * To investigate whether the VEGF-targeted…
This study investigates the safety and tolerability of deferoxamine use in patients with aneurysma subarachnoid hemorrhage.
To enhance our knowledge concerning the effectiveness of tDCS in the rehabilitation of stroke patients. Next to this, the results will also contribute to our knowledge concerning the role of the parietal cortex in episodic memory and attentional…
Peroperative assessment of the heart's microcirculation during coronary arterial bypass surgery (CABG) with incident dark filed imaging
To determine the safety of the MobiusHD System and the efficacy of the MobiusHD device in lowering mean systolic 24-hour ambulatory blood pressure in subjects with resistant hypertension. The hypothesis is that mean systolic 24-hour ambulatory blood…
Specific Aim #1: To evaluate the efficacy and safety of shortened-duration (6 weeks total) versus conventional duration (3 months total) anticoagulation for first-episode, provoked, acute venous thrombosis among children in whom thrombus resolution/…
To evaluate the safety and effectiveness of the BackBeat Moderato system.
Aim 1: Confirm the hypothesis that the IgG4 qPCR test score correlates with disease activity in vasculitis as observed in the pilot study. Aim 2: Study IgG4-expressing B-cells from blood of vasculitis patients to understand their role in the…
Primary objective: To investigate whether AS patients have increased signs of microvascular abnormalities of the retina, compared with healthy controls.Secondary objectives: to investigate:1. the peripheral microvascular function in AS patients,…
To prospectively study the effect of salt restriction on the rise in blood pressure in response to anti-cancer treatment with the VEGF inhibitor sunitinib and regorafenib.
The objective of this study is to determine the incidence of chronic Q fever and seronegativity in vascular patients that were seropositive after the Dutch Q fever outbreak. Seropositivity can indicate a past resolved Q fever infection or chronic Q…
To determine the feasibility of spatial and temporal quantification of blood flow near stents in the superficial femoral artery, using contrast enhanced ultrasound (CEUS) in high framerate (HFR) and particle image velocimetry (PIV).
The objective of the study is to assess the safety and performance of the Shockwave Medical, Inc. Coronary Lithoplasty® System to treat calcified, stenotic, de novo coronary lesions prior to stenting in a real-world post-market study.
To evaluate the tolerability (adverse effects) of 99mTc-Fucoidan in 10 healthy volunteers (phase I).
This study aims at investigating potential relevant QT effects of clazosentan at supra therapeutic doses in healthy male and female subjects using a concentration/response analysis approach in compliance with the ICH E14 guidance [FDA 2017].Primary…
Primary Objective: To compare the fetal/maternal ratio of nifedipine blood concentrations between pregnancies with and without hypertensive disorders, including preeclampsia.Secondary Objective: To compare predicted fetal/maternal drug ratios with…
Is it possible to detect prothrombotic states via the "calibrated automated thrombogram" in patients that endured CVST, who did no show deviations in the prothrombin time/activated partial thromboplastin time? Secondary, we will…