83 results
To gain further insight into the interaction and possibly shared pathophysiological mechanisms of female-specific cardiovascular risk factors and events we will quantify white matter hyperintensities on brain MRI and assess endothelial function in…
PROFITS aims to improve prognostic models for functional outcome in a broad cohort of 160 stroke patients. PROFITS will:1) Uniformly assess determinants for recovery of functional outcome starting in the first week after stroke and functional…
To compare the safety and efficacy of the Tack Endovascular System* in subjects with peripheral artery disease (PAD) to a pre-defined performance goal (PG).
This study aims at (further) revealing the pathophysiology of intestinal IR in man, with a specific interest for the role of proteases and protease-activated receptor-2 (PAR-2), cellular and inflammatory changes, barrier function and intestinal…
The primary objective for this study is to evaluate the cerebrovascular reactivity of HCHWA-D patients:1. To compare the (autoregulatory) function of small brain vessels in HCHWA-D patients with matched controls using the cerebrovascular reactivity…
To evaluate the post-market performance of the GORE® VIABAHN® Endoprosthesis for the treatment of in-stent restenosis in the superficial femoral artery.
Primary Objective:- To assess lipid levels of STEMI patients over a long course. Secondary Objectives:- To assess the association between poorly controlled cholesterol and (apo) lipoprotein levels for the long term outcome in STEMI patients.- To…
The aim of the present study is to determine the effect of vaccination on anti-oxLDL antibodies in man.
Based on the gaps in our knowledge (as stated above), we have formulated the following objectives:- To quantify the degree of hepatic fat accumulation and fibrosis in patients with HFI. - To gain more insight in the mechanism leading to NAFLD in…
4.1 The main questionWhat is the effect of temporarily stopping PPI use on the stomach wall uptake of Tc99m Sestamibi with a myocardial perfusion?4.2 Sub-questions:- What is the relative maagwanduptake a myocardial perfusion Tc99m Sestamibi with…
To assess intra- and interpatient variability of plasma Mg concentration before and after hemodialysis.
The main goal is to assess differences in the maximal BP response compared to baseline using beat-to-beat registration of BP between subjects with and without established differences between home and ambulatory BP of at least 10/5 mmHg. As a…
Assess feasibility of development of skin colour independent assessment of skin AGE accumulation by measurement of skin autofluorescence in persons with dark skin
The aim of the present study is to identify the association of inflammation in PsA with measures of abdominal fat and cardiometabolic risk factors and evaluate the body composition changes in PsA patients receiving apremilast. Secondly, to assess…
To determine the feasibility of the MitoPO2 measurements during upper endoscopy.
The purpose of this study is to advance our understanding of the behaviour of the coronary microcirculation in the setting of NSTE-ACS, to provide insights into the relationship between Doppler flow velocity and thermodilution-derived coronary…
The purpose of the current study is to determine whether LHW090 displays the clinical safety and efficacy profile to support further development for resistant hypertension.
In this exploratory study we aim to explore the values of apolipoprotein B bound to erythrocytes in patients with diabetes mellitus type 1 or 2, to evaluate the relationship with clinical and subclinical atherosclerosis and to compare these results…
To explore the inflammatory changes of a PCSK-9 inhibitor compared with placebo on postprandial lipemia and postprandial leukocyte activation, oxidative stress and endothelial function in men with type 2 diabetes mellitus.
See chapter 'objectives' of study protocol (page 12)