88 results
The primary objective is to compare initial PTA with supervised exercise therapy for patients with disabling intermittent claudication due to an iliac artery lesion in terms of mobility, functional status, health related quality of life and cost-…
1) to investigate cognitive functioning in lacunar infarct patients with and without periventricular white matter lesions; 2) to identify predictors for cognitive dysfunction in lacunar infarct patients.
The main objective is to show whether imaging characteristics assessed at baseline can predict clinical events in patients with a 30-69 % symptomatic carotid stenosis.
PrimaryTo investigate sensitivity and specificity of 3.0 Tesla MRI and MRS for dimension and composition assessment of carotid artery plaques, in particularly those plaques with lipid rich necrotic cores (LRNC), with the aim to develop these…
To determine the relationship between pericoronary adipose tissue (dys)function, in terms of the cytokine and adipokine secretion profile and histologic markers of inflammation, and coronary atherosclerosis.
1. Does mPAT directly impair vasoreactivity to insulin and acetylcholine ex vivo in arterioles obtained from muscle biopsy in lean and obese individuals?2. Is obesity in humans associated with the accumulation of mPAT and an inflammatory mPAT…
ObjectiveTo investigate the performance of paclitaxel-coated balloon expandable stainless steel coronary stent for the treatment of infrapopliteal stenoses and occlusions in patients with critical limb ischemia compared to percutaneous transluminal…
The objective of the study is to examine the relation between changes in cortical activity during movement observation and execution, and changes in motor function and motor control after stroke. The hypotheses to study this objective are: 1. Brain…
To examine whether a self-help psychological intervention program, based on relaxation, changing negative coping styles and finding new goals would be useful for people with PAD.
In this study the effects of a two-week moderately intense-intense physical activity on vascular function, glucose-metabolism, lipid-metabolism and adipose tissue function will be analyzed.
This study aims to show by which technique the patient feels the least pain. It is also designed to show which advantages and disadvantages are linked to the abovementioned forms of anesthesia and if there are differences in postoperative pain…
The primary objective of this study is to evaluate the diagnostic accuracy of coronary artery luminal stenosis and corresponding myocardium perfusion defects in patients with suspected coronary artery disease by use of volume computed tomography..…
Following the participants three more years will enable us to get a better overview of the consequences of the screening with regard to treatment, health, lifestyle modifications and illness perception with regard to obesity. Primary Objective: • To…
Inflammatory and endothelial parametersTo investigate the influence of factor VIII concentrate infusion on inflammatory and endothelial parameters in patients with severe hemophilia A.Platelet activity and responsivenessTo investigate the influence…
a) To investigate the differences in adipokines and inflammatory markers between obese and normal weight children; b) to study these differences over age, and c) to correlate adipokine/inflammatory marker profiles to clinical parameters for obesity…
1. FDG PET scanning will permit evaluation of atherosclerotic disease in lower limbs (both density and activity of macrophages in local plaques) in patients with diabetes type 2 2. To obtain a more precise identification of ischemic borders…
The aim of the study described in this protocol is the identification of genes involved in aortic aneurysm development. This will be achieved by characterization of large AA families, including pedigree investigations, diagnostic measurements (…
The objectives are to explore in a step-wise approach the possibility to study reactive hyperemia and ischemia-reperfusion phenomena in humans by simultaneous assessment of vaso-reactivity and autonomous nervous system function.
Primary Objective: To determine whether a four week treatment with vildagliptin compared to acarbose improves endothelial dysfunction in patients with type 2 diabetes mellitus.Secondary Objective(s):-To determine the effect of vildagliptin on plasma…
To collect information of 1000 patients per coumarin (acenocoumarol and phenprocoumon) to investigate the impact of height and weight on the dose needed. The database will also contain other information of the patient, like age, gender and genotypes…