4530 results
The null hypothesis of the primary outcome measure is that there will be no significant differences in DASH scores 6 months after surgery between patients who underwent plate fixation or intramedullary fixation with a TEN. The alternate hypothesis…
Dental caries lesions (with ICDAS Codes 3 and 4) can be treated by sealing, offering a less invasive and less costly treatment option with the same results as preparation and restoration of the carious lesions.
1. Cysteine is an essential amino acid for newborn preterm infants; 2. Cysteine requirements change rapidly with postnatal age; 3. The change in cysteine requirement with age is based upon cystathionase activity; 4. Intestinal cystathionase activity…
The primary objective is to demonstrate the non-inferiority of bevacizumab to ranibizumab in the treatment of patients with subfoveal CNV secondary to AMD as determined by the change in best-corrected visual acuity in the study eye from baseline to…
The primary aim of this split-mouth randomized clinical trial is to assess accuracy of bracket positioning of a fully digital IDB workflow compared to a DBB workflow, with IDB bracket planning serving as reference for both methods. The secondary…
Radiofrequency ablation (RFA) will lead to permanent and complete eradication of Barrett's epithelium. This will prevent development of high grade intraepithelial neoplasia (HGIN) or early carcinoma and may eliminate the need for endoscopic…
Changing the context in which individuals make lifestyle choices has a sustained impact on the dietary intake and cardiometabolic health.
1. The intervention is effective in reducing eating disorder symptoms; 2. There is an incremental effect of intensive/frequent support from a coach in terms of reducing ED symptoms.
To compare the efficacy of maintenance therapy with an equal monthly dose of imiglucerase when administered at a frequency of once every four weeks versus once every one or two weeks, in adult type I Gaucher disease patients in stable and good…
1. A multidimensional lifestyle intervention, including aspects of increased awareness, motivation, self-management, diet, exercise, and a supportive environment, improves or prevents deterioration of the cardiometabolic risk factors of SMI…
What is the effectiveness of low doses of haloperidol and regular doses of amisulpride, olanzapine, quetiapine, and ziprasidone on (loss of) one year retention in patients with recent onset of schizophrenia, schizoaffective, and schizophreniform…
NT-proBNP guidance during in-hospital treatment of acutely decompensated heart failure (to strive for >30% reduction) reduces readmissions and mortality and increases the number of days alive out of hospital in the first 180 days.
Subacromial disorders are considered to be the most common pathology affecting the shoulder. The optimal therapy for shoulder pain (SP) in primary care is yet unknown, since clinical history and physical examination do not provide decisive evidence…
At least 90% of the subjects, with 95% confidence, will tolerate the test formula.
We expect that parents involved in the program (as compared to controls) will be more involved in high qualitative communication on alcohol topics, have more confidence in discussing alcohol matters and greater efficacy to prevent their children…
Custom made orthotic insoles by a podiatrist are (cost)effective in reducing pain and improving function in patients with plantar fasciitis compared to sham orthotic insoles and education alone.
Simular outcomes in patients with 4 implants compared with patients with 6 implants with respects to peri-implant bone level stability
During chronic HIV-1 infection the immune system is chronically hyperactivated. This hyperactivation is considered as the main cause of CD4+ T-cell loss. Furthermore, HIV replicates most efficiently in activated CD4+ T-cells. In this study we try to…
We hypothesize that an initial CPAP level of 15 cmH2O followed by down titration to 8 cmH2O is better CPAP strategy for preterm infants at birth when compared to the currently used initial CPAP level of 5 cmH2O followed by up-titration to 8 cmH2O…
We want to test the hypothesis that internet based guided self-help is not more expensive and not less effective than usual care for patients with phobias.