1653 results
Primary ObjectiveTo evaluate the effect of a tailored behavioral change intervention comprising CBT and physical activity on participation (as measured by the DM1-Activ scale) for severely fatigued patients with myotonic dystrophy type 1 compared to…
To investigate what the ideal moment to vaccinate would be, early (after 2-6 months) or late (after 9-12 months) after cessation of rituximab. Secondly to study the immune-response to vaccination with influenza virus vaccine after treatment with…
Theoretically the anatomical reconstruction technique should give better results in rotational stability due to a more anatomical placement of the ACL-graft. Though it is difficult to test this correlating to functional outcome, because in current…
The primary objective in this observational study is to determine microcirculatory profile in preterm and term neonates. We would like to determine how the microcirculation changes in time during the phase of adaptation and correlate inter- and…
The aim of this study is to determine whether the presence and the extent of periodontitis are independently related to the presence and extent of coronary calcification.To determine if periodontal treatment has an positive effect on the…
The main objective of this study is to measure executive functions at two levels. First we will compare the results of neuropsychological testing in elderly with autism and compare these findings to elderly without autism. Secondly we will compare…
The purpose of the study is to investigate the safety and effectiveness of the HF IF PIOL, and to compare performance with the Artiflex lens. Study outcomes will be used to obtain CE marking for the lens and for registration and marketing purposes.
We aim to identify biomarkers (from neuroimaging, eye tracking, EEG, cognition, biochemistry, proteomics, genomics) for stratification of ASD. Biomarkers will be crucial to aid more accurate and earlier diagnosis of ASD. They are also needed for…
To detect ophthalmic differences between patients and controles. To detect (early) changes in the retina in (pre)symptomatic HCHWA-D disease carriers, in order to find a *biomarker* for disease stage and progression.
To examine the long-term effects of a CT- and/or RT-induced premature menopause on BMD, cardiovascular status, neurocognitive function and QoL in female HL survivors.
The main, primary objective of this study is identification of the molecular mechanisms that regulate structure and function of red blood cells in patients with neurodegeneration accompanied by the presence of abnormal red blood cells (…
1. What is the somatosensory profile of DM2 patients?2. What are the similarities and differences between the somatosensory profile of pain in myotonic dystrophy type 2 and fibromyalgia patients?
As only a subgroup of breast cancer patients experience long-term cognitive decline after adjuvant chemotherapy, it is critical to identify risk factors for this decline. Some risk factor like higher age, lower cognitive reserve (either defined as…
The general aim of this study is to implement validated markers for CAA in asymptomatic individuals with CMBs, to investigate whether presence of CMBs signifies early CAA.
This protocol involves studies that aim at:1. A better understanding of sensory perception and eating behaviour2. Validation of newly developed sensory and behavioural methods3. To determine the effect of fat, sugar and/or salt reduction on sensory…
Primary: 1. To determine what the effect of exercise on coagulation.2. Establish the changes in bloodcell counts as a result of exercise.3. What the effect of exercise is on the platelet function.4. To test the different effects of cycling and…
Our objective is to test the feasibility and preliminary effects of a web-based patient portal containing a survivorship care plan, online questionnaires for symptoms and HRQL with personalized feedback and a physical activity support programme that…
Primary Objective: To quantify the tissue light scattering, absorbing and fluorescence properties of different stages of skin (pre)cancer using multi-diameter single fiber reflectance (MDSFR) spectroscopy. Secondary Objective(s): To correlate the…
To assess whether close rectal restorative proctocolectomy with IPAA has a better outcome regarding postoperative vaginal vasocongestion and reported psychological and sexual functioning then IPAA by TME restorative proctocolectomy.
1. Is there a difference between the level of activities and participation among adolescents with chronic musculoskeletal pain as compared with the activity and participation level of adolescents not suffering from chronic pain?2. What is the impact…